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Title: Crystal structures of amyloidogenic segments of human transthyretin: Amyloid Structures of Transthyretin Segments

Journal Article · · Protein Science
DOI:https://doi.org/10.1002/pro.3420· OSTI ID:1459976
ORCiD logo [1];  [1];  [1];  [1]
  1. Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, Box 951570, UCLA, Howard Hughes Medical Institute, UCLA-DOE Institute, Los Angeles California 90095-1570

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
UNIVERSITY
OSTI ID:
1459976
Journal Information:
Protein Science, Vol. 27, Issue 7; ISSN 0961-8368
Publisher:
The Protein Society
Country of Publication:
United States
Language:
ENGLISH

References (29)

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates journal December 2012
Shape Complementarity at Protein/Protein Interfaces journal December 1993
The Amyloid State of Proteins in Human Diseases journal March 2012
Structural Studies of Amyloid Proteins at the Molecular Level journal June 2017
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Amyloid deposits in transthyretin-derived amyloidosis: cleaved transthyretin is associated with distinct amyloid morphology journal January 2005
Molecular basis for amyloid-  polymorphism journal September 2011
Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS) journal July 2017
Transthyretin (Prealbumin) in Health and Disease: Nutritional Implications journal July 1994
Identifying the amylome, proteins capable of forming amyloid-like fibrils journal February 2010
Solvent-accessible surfaces of proteins and nucleic acids journal August 1983
Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis journal December 2015
Atomic structure and hierarchical assembly of a cross-  amyloid fibril journal March 2013
Atomic structures of amyloid cross-β spines reveal varied steric zippers journal April 2007
Relaxation of backbone bond geometry improves protein energy landscape modeling: Relaxation of Backbone Bond Geometry journal November 2013
Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å journal May 1978
Structure-based inhibitors of tau aggregation journal November 2017
Amyloidogenic and non-amyloidogenic transthyretin variants interact differently with human cardiomyocytes: insights into early events of non-fibrillar tissue damage journal January 2015
Atomic View of a Toxic Amyloid Small Oligomer journal March 2012
The interpretation of protein structures: Estimation of static accessibility journal February 1971
Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. Cohen journal October 1997
Molecular mechanisms for protein-encoded inheritance journal August 2009
Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets journal January 2016
Automated Structure Solution with the PHENIX Suite book January 2008
The 3D profile method for identifying fibril-forming segments of proteins journal March 2006
Structure of the cross-β spine of amyloid-like fibrils journal June 2005
Phaser crystallographic software journal July 2007
A new amyloidogenic transthyretin variant, [D38A], detected by electrospray ionization / mass spectrometry journal January 1999
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients journal September 2017

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