Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Rare HIV-1 Subtype J Genomes and a New H/U/CRF02_AG Recombinant Genome Suggests an Ancient Origin of HIV-1 in Angola

Journal Article · · AIDS Research and Human Retroviruses
 [1];  [1];  [1];  [2];  [3]
  1. Univ. of Lisbon (Portugal). Research Inst. for Medicines (iMed.Ulisboa) and Faculty of Pharmacy
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Univ. of Lisbon (Portugal). Research Inst. for Medicines (iMed.Ulisboa) and Faculty of Pharmacy; Higher Inst. of Health Sciences Egas Moniz, Almada (Portugal). Center for Interdisciplinary Research Egas Moniz (CiiEM)
+ Show Author Affiliations
Angola has an extremely diverse HIV-1 epidemic fueled in part by the frequent interchange of people with the Democratic Republic of Congo (DRC) and Republic of Congo (RC). Characterization of HIV-1 strains circulating in Angola should help to better understand the origin of HIV-1 subtypes and recombinant forms and their transmission dynamics. In this work we characterize the first near full-length HIV-1 genomic sequences from HIV-1 infected individuals from Angola. Samples were obtained in 1993 from three HIV-1 infected patients living in Cabinda, Angola. Near full-length genomic sequences were obtained from virus isolates. Maximum likelihood phylogenetic tree inference and analyses of potential recombination patterns were performed to evaluate the sequence classifications and origins. Phylogenetic and recombination analyses revealed that one virus was a pure subtype J, another mostly subtype J with a small uncertain region, and the final virus was classified as a H/U/CRF02_AG recombinant. Consistent with their epidemiological data, the subtype J sequences were more closely related to each other than to other J sequences previously published. Based on the env gene, taxa from Angola occur throughout the global subtype J phylogeny. HIV-1 subtypes J and H are present in Angola at low levels since at least 1993. Low transmission efficiency and/or high recombination potential may explain their limited epidemic success in Angola and worldwide. The high diversity of rare subtypes in Angola suggests that Angola was part of the early establishment of the HIV-1 pandemic.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
European Union (EU); Foundation for Science and Technology (FCT) (Portugal); National Inst. of Health (NIH); USDOE
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1459811
Report Number(s):
LA-UR--16-27497
Journal Information:
AIDS Research and Human Retroviruses, Journal Name: AIDS Research and Human Retroviruses Journal Issue: 8 Vol. 32; ISSN 0889-2229
Country of Publication:
United States
Language:
English

References (19)

HIV-1 genetic variants circulation in the North of Angola journal April 2005
Highly divergent subtypes and new recombinant forms prevail in the HIV/AIDS epidemic in Angola: New insights into the origins of the AIDS pandemic journal July 2009
Characterization of novel recombinant HIV-1 genomes using the branching index journal November 2003
Identification of Two CRF11-cpx Genomes and Two Preliminary Representatives of a New Circulating Recombinant Form (CRF13-cpx) of HIV Type 1 in Cameroon journal August 2002
High Genetic Diversity of Human Immunodeficiency Virus Type 1 in Angola journal April 2005
HIV Type 1 CRF13_cpx Revisited: Identification of a New Sequence from Cameroon and Signal for Subsubtype J2 journal November 2005
jpHMM at GOBICS: a web server to detect genomic recombinations in HIV-1 journal July 2006
jpHMM: Improving the reliability of recombination prediction in HIV-1 journal May 2009
Classification of hepatitis C virus and human immunodeficiency virus-1 sequences with the branching index journal September 2008
Antiretroviral Drug Resistance Surveillance among Treatment-Naive Human Immunodeficiency Virus Type 1-Infected Individuals in Angola: Evidence for Low Level of Transmitted Drug Resistance journal July 2009
Non-M Variants of Human Immunodeficiency Virus Type 1 journal July 2013
Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications journal October 2007
Virological and Molecular Demonstration of Human Immunodeficiency Virus Type 2 Vertical Transmission journal April 1998
HIV-1 Genetic Variability and Clinical Implications journal June 2013
HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics journal January 2013
Recombination Enhances HIV-1 Envelope Diversity by Facilitating the Survival of Latent Genomic Fragments in the Plasma Virus Population journal December 2015
HIV-1 Diversity, Transmission Dynamics and Primary Drug Resistance in Angola journal December 2014
The origin and molecular epidemiology of HIV journal September 2013
Baseline susceptibility of primary HIV-2 to entry inhibitors journal January 2012

Cited By (3)

Sensitive Next-Generation Sequencing Method Reveals Deep Genetic Diversity of HIV-1 in the Democratic Republic of the Congo journal January 2017
Early infant diagnosis of HIV-1 infection in Luanda, Angola, using a new DNA PCR assay and dried blood spots journal July 2017
Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa journal December 2019

Similar Records

HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form
Journal Article · Fri Oct 08 20:00:00 EDT 2010 · Retrovirology · OSTI ID:1626608
Molecular Epidemiology of HIV-1 in Ghana: Subtype Distribution, Drug Resistance and Coreceptor Usage
Journal Article · Fri Dec 30 19:00:00 EST 2022 · Viruses · OSTI ID:1908490
Identification of a new circulating recombinant form of human immunodeficiency virus type 1, CRF124_cpx involving subtypes A, G, H, and CRF27_cpx in Angola
Journal Article · Sun Oct 16 20:00:00 EDT 2022 · Frontiers in Microbiology · OSTI ID:2470548

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES