Microdosimetry of Radon Progeny: Application to Risk Assessment

Conference · Sat Jun 01 04:00:00 EDT 1991

OSTI ID:145669

Fisher, Darrell R. ^[1]; Hui, T. Edmond ^[1]; Bond, Victor P. ^[2]; James, Anthony C. ^[1]

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1. Pacific Northwest Laboratory (PNL), Richland, WA (United States)
2. Brookhaven National Laboratory (BNL), Upton, NY (United States)

We developed methods for calculating radiation doses to individual cells and cell nuclei of human bronchial epithelium from radon and progeny for specified levels of exposure, breathing rates, equilibrium factors, unattached fraction of progeny, and other factors that are important in radon dosimetry. If we also know which cells are likely precursors for cancer, and we also know their locations in the respiratory tract, we then may calculate the statistical probability that these cells are irradiated by alpha particles, the number of single alpha-particle hits, and the spectrum of doses delivered (as a probability density in specific energy).

• Research Organization: Pacific Northwest Laboratory (PNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC06-76RL01830; AC02-76CH00016
• OSTI ID: 145669
• Report Number(s): PNL-SA--18325; BNL--48739; CONF-901010--6; ON: DE91015266
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ALPHA PARTICLES
BRONCHI
CARCINOGENESIS
DAUGHTER PRODUCTS
DOSE-RESPONSE RELATIONSHIPS
EPITHELIUM
INFORMATION NEEDS
LOCAL RADIATION EFFECTS
LUNGS
MATHEMATICAL MODELS
MICRODOSIMETRY
MONTE CARLO METHOD
NEOPLASMS
POLONIUM 214
POLONIUM 218
PROBABILISTIC ESTIMATION
RADIATION DOSES
RADIATION HAZARDS
RADON 222
RESPIRATORY TRACT CELLS
RISK ASSESSMENT