Reversible Self-Assembly of Glutathione-Coated Gold Nanoparticle Clusters via pH-Tunable Interactions

Moaseri, Ehsan; Bollinger, Jonathan A.; Changalvaie, Behzad; Johnson, Lindsay; Schroer, Joseph; Johnston, Keith P.; Truskett, Thomas M.

doi:10.1021/acs.langmuir.7b02446

Reversible Self-Assembly of Glutathione-Coated Gold Nanoparticle Clusters via pH-Tunable Interactions

Journal Article · Fri Oct 06 00:00:00 EDT 2017 · Langmuir

DOI:https://doi.org/10.1021/acs.langmuir.7b02446· OSTI ID:1441463

Moaseri, Ehsan ^[1]; Bollinger, Jonathan A. ^[2]; Changalvaie, Behzad ^[3]; Johnson, Lindsay ^[1]; Schroer, Joseph ^[1]; ^[4]; ^[1]

Univ. of Texas, Austin, TX (United States). McKetta Department of Chemical Engineering
Univ. of Texas, Austin, TX (United States). McKetta Department of Chemical Engineering; Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Center for Integrated Nanotechnologies
Univ. of Texas, Austin, TX (United States). Texas Materials Institute
Univ. of Texas, Austin, TX (United States). McKetta Department of Chemical Engineering and Texas Materials Institute

In this study, nanoparticle (NP) clusters with diameters ranging from 20 to 100 nm are reversibly assembled from 5 nm gold (Au) primary particles coated with glutathione (GSH) in aqueous solution as a function of pH in the range of 5.4 to 3.8. As the pH is lowered, the GSH surface ligands become partially zwitterionic and form interparticle hydrogen bonds that drive the self-limited assembly of metastable clusters in <1 min. Whereas clusters up to 20 nm in size are stable against cluster–cluster aggregation for up to 1 day, clusters up to 80 nm in size can be stabilized over this period via the addition of citrate to the solution in equal molarity with GSH molecules. The cluster diameter may be cycled reversibly by tuning pH to manipulate the colloidal interactions; however, modest background cluster–cluster aggregation occurs during cycling. Cluster sizes can be stabilized for at least 1 month via the addition of PEG-thiol as a grafted steric stabilizer, where PEG-grafted clusters dissociate back to starting primary NPs at pH 7 in fewer than 3 days. Whereas the presence of excess citrate has little effect on the initial size of the metastable clusters, it is necessary for both the cycling and dissociation to mediate the GSH–GSH hydrogen bonds. In conclusion, these metastable clusters exhibit significant characteristics of equilibrium self-limited assembly between primary particles and clusters on time scales where cluster–cluster aggregation is not present.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1441463

Report Number(s):: SAND--2018-4149J; 662768

Journal Information:: Langmuir, Journal Name: Langmuir Journal Issue: 43 Vol. 33; ISSN 0743-7463

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Reversible Self-Assembly of Glutathione-Coated Gold Nanoparticle Clusters via pH-Tunable Interactions

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