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Title: Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins

Abstract

Protactinium-230 (t1/2 = 17.4 d) is the parent isotope of 230U (t1/2 = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added 230Pa from proton irradiated thorium targets and accompanying fission products. Results reported within this paper demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of 230Pa was 93 ± 4% employing a R3P=S type commercially available resin and 88 ± 4% employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin. The radiochemical purity of the recovered 230Pa was measured via high purity germanium γ-ray spectroscopy to be >99.5% with the remaining radioactive contaminant being 95Nb due to its similar chemistry to protactinium. Finally, measured equilibrium distribution coefficients for protactinium, thorium, uranium, niobium, radium, and actinium on both the R3P=S type and the DGTA resin in hydrochloric acid media are reported, to the best of our knowledge, for the first time.

Authors:
 [1];  [1];  [1];  [1];  [2];  [2];  [2];  [1];  [1];  [1];  [1];  [1]; ORCiD logo [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP)
OSTI Identifier:
1440455
Report Number(s):
LA-UR-18-22616
Journal ID: ISSN 0003-2700; TRN: US1900741
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Analytical Chemistry
Additional Journal Information:
Journal Volume: 90; Journal Issue: 11; Journal ID: ISSN 0003-2700
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Mastren, Tara, Stein, Benjamin W., Parker, T. Gannon, Radchenko, Valery, Copping, Roy, Owens, Allison, Wyant, Lance E., Brugh, Mark, Kozimor, Stosh A., Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins. United States: N. p., 2018. Web. doi:10.1021/acs.analchem.8b01380.
Mastren, Tara, Stein, Benjamin W., Parker, T. Gannon, Radchenko, Valery, Copping, Roy, Owens, Allison, Wyant, Lance E., Brugh, Mark, Kozimor, Stosh A., Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., & Fassbender, Michael E. Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins. United States. https://doi.org/10.1021/acs.analchem.8b01380
Mastren, Tara, Stein, Benjamin W., Parker, T. Gannon, Radchenko, Valery, Copping, Roy, Owens, Allison, Wyant, Lance E., Brugh, Mark, Kozimor, Stosh A., Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. 2018. "Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins". United States. https://doi.org/10.1021/acs.analchem.8b01380. https://www.osti.gov/servlets/purl/1440455.
@article{osti_1440455,
title = {Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins},
author = {Mastren, Tara and Stein, Benjamin W. and Parker, T. Gannon and Radchenko, Valery and Copping, Roy and Owens, Allison and Wyant, Lance E. and Brugh, Mark and Kozimor, Stosh A. and Nortier, F. Meiring and Birnbaum, Eva R. and John, Kevin D. and Fassbender, Michael E.},
abstractNote = {Protactinium-230 (t1/2 = 17.4 d) is the parent isotope of 230U (t1/2 = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added 230Pa from proton irradiated thorium targets and accompanying fission products. Results reported within this paper demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of 230Pa was 93 ± 4% employing a R3P=S type commercially available resin and 88 ± 4% employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin. The radiochemical purity of the recovered 230Pa was measured via high purity germanium γ-ray spectroscopy to be >99.5% with the remaining radioactive contaminant being 95Nb due to its similar chemistry to protactinium. Finally, measured equilibrium distribution coefficients for protactinium, thorium, uranium, niobium, radium, and actinium on both the R3P=S type and the DGTA resin in hydrochloric acid media are reported, to the best of our knowledge, for the first time.},
doi = {10.1021/acs.analchem.8b01380},
url = {https://www.osti.gov/biblio/1440455}, journal = {Analytical Chemistry},
issn = {0003-2700},
number = 11,
volume = 90,
place = {United States},
year = {2018},
month = {5}
}

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Free Publicly Available Full Text
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Figures / Tables:

Figure 1 Figure 1: Decay scheme of 230Pa.

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Works referenced in this record:

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journal, April 1997


and contamination at zero age: a possible limitation on U/Th series dating of speleothem material
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Works referencing / citing this record:

Microfluidics-based separation of actinium-225 from radium-225 for medical applications
journal, May 2019


Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.