Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins

Mastren, Tara; Stein, Benjamin W.; Parker, T. Gannon; Radchenko, Valery; Copping, Roy; Owens, Allison; Wyant, Lance E.; Brugh, Mark; Kozimor, Stosh A.; Nortier, F. Meiring; Birnbaum, Eva R.; John, Kevin D.; Fassbender, Michael E.

doi:10.1021/acs.analchem.8b01380

Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins

Journal Article · Mon May 14 00:00:00 EDT 2018 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.8b01380· OSTI ID:1440455

Mastren, Tara ^[1]; Stein, Benjamin W. ^[1]; Parker, T. Gannon ^[1]; Radchenko, Valery ^[1]; Copping, Roy ^[2]; Owens, Allison ^[2]; Wyant, Lance E. ^[2]; Brugh, Mark ^[1]; Kozimor, Stosh A. ^[1]; Nortier, F. Meiring ^[1]; Birnbaum, Eva R. ^[1]; John, Kevin D. ^[1]; ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division

Protactinium-230 (t_1/2 = 17.4 d) is the parent isotope of ²³⁰U (t_1/2 = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added ²³⁰Pa from proton irradiated thorium targets and accompanying fission products. Results reported within this paper demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of ²³⁰Pa was 93 ± 4% employing a R₃P=S type commercially available resin and 88 ± 4% employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin. The radiochemical purity of the recovered ²³⁰Pa was measured via high purity germanium γ-ray spectroscopy to be >99.5% with the remaining radioactive contaminant being ⁹⁵Nb due to its similar chemistry to protactinium. Finally, measured equilibrium distribution coefficients for protactinium, thorium, uranium, niobium, radium, and actinium on both the R₃P=S type and the DGTA resin in hydrochloric acid media are reported, to the best of our knowledge, for the first time.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: AC05-00OR22725; AC52-06NA25396

OSTI ID:: 1440455

Alternate ID(s):: OSTI ID: 1842640

Report Number(s):: LA-UR--18-22616

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 11 Vol. 90; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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