TMBIM-mediated Ca2+ homeostasis and cell death

Liu, Qun

doi:10.1016/j.bbamcr.2016.12.023

Title: TMBIM-mediated Ca2+ homeostasis and cell death

Journal Article · Thu Jun 01 00:00:00 EDT 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI:https://doi.org/10.1016/j.bbamcr.2016.12.023· OSTI ID:1439911

Ca²⁺ is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca²⁺ is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi Apparatus maintain high-concentration Ca²⁺ stores. Under resting conditions, store Ca²⁺ homeostasis is dynamically regulated to equilibrate between active Ca²⁺ uptake and passive Ca²⁺ leak processes. The evolutionarily conserved Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) proteins mediate Ca²⁺ homeostasis and cell death. This review focuses on recent advances in functional and structural analysis of TMBIM proteins in regulation of the two related functions. The roles of TMBIM proteins in pathogen infection and cancer are also discussed with prospects for treatment.

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Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: LDRD 15-034; GM107462; SC0012704

OSTI ID:: 1439911

Alternate ID(s):: OSTI ID: 1389232

Report Number(s):: BNL-114189-2017-JA; S0167488917300010; PII: S0167488917300010

Journal Information:: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Name: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Vol. 1864 Journal Issue: 6; ISSN 0167-4889

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

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Cited by: 29 works

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Fas/CD95 Regulatory Protein Faim2 Is Neuroprotective after Transient Brain Ischemia Reich, A.; Spering, C.; Gertz, K. Journal of Neuroscience, Vol. 31, Issue 1 https://doi.org/10.1523/JNEUROSCI.2188-10.2011	journal	January 2011
Bax Inhibitor-1, a Conserved Cell Death Suppressor, Is a Key Molecular Switch Downstream from a Variety of Biotic and Abiotic Stress Signals in Plants Watanabe, Naohide; Lam, Eric International Journal of Molecular Sciences, Vol. 10, Issue 7 https://doi.org/10.3390/ijms10073149	journal	July 2009
Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis Ouyang, L.; Shi, Z.; Zhao, S. Cell Proliferation, Vol. 45, Issue 6 https://doi.org/10.1111/j.1365-2184.2012.00845.x	journal	October 2012
The BCL-2 protein family: opposing activities that mediate cell death Youle, Richard J.; Strasser, Andreas Nature Reviews Molecular Cell Biology, Vol. 9, Issue 1 https://doi.org/10.1038/nrm2308	journal	January 2008
Alterations of calcium homeostasis in cancer cells Marchi, Saverio; Pinton, Paolo Current Opinion in Pharmacology, Vol. 29 https://doi.org/10.1016/j.coph.2016.03.002	journal	August 2016
Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak Einsele-Scholz, Stephanie; Malmsheimer, Silke; Bertram, Katrin Journal of Cell Science, Vol. 129, Issue 11 https://doi.org/10.1242/jcs.181727	journal	April 2016

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Human cytomegalovirus US21 protein is a viroporin that modulates calcium homeostasis and protects cells against apoptosis Luganini, Anna; Di Nardo, Giovanna; Munaron, Luca Proceedings of the National Academy of Sciences, Vol. 115, Issue 52 https://doi.org/10.1073/pnas.1813183115	journal	December 2018
BAX inhibitor‐1: between stress and survival Lebeaupin, Cynthia; Blanc, Marina; Vallée, Déborah The FEBS Journal, Vol. 287, Issue 9 https://doi.org/10.1111/febs.15179	journal	January 2020
Sodium/Hydrogen Exchanger 1 Participates in Early Brain Injury after Subarachnoid Hemorrhage both in vivo and in vitro via Promoting Neuronal Apoptosis Song, Huangcheng; Yuan, Shuai; Zhang, Zhuwei Cell Transplantation, Vol. 28, Issue 8 https://doi.org/10.1177/0963689719834873	journal	March 2019
Expression of TMBIM6 in Cancers: The Involvement of Sp1 and PKC Junjappa, Raghu Patil; Kim, Hyun-Kyoung; Park, Seong Yeol Cancers, Vol. 11, Issue 7 https://doi.org/10.3390/cancers11070974	journal	July 2019

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