Multivariate Analysis To Quantify Species in the Presence of Direct Interferents: Micro-Raman Analysis of HNO₃ in Microfluidic Devices

Journal Article · Tue Jan 30 04:00:00 EST 2018 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.7b03833· OSTI ID:1439670

Lines, Amanda M. ^[1]; Nelson, Gilbert L. ^[2]; Casella, Amanda J. ^[1]; Bello, Job M. ^[3]; Clark, Sue B. ^[4]; Bryan, Samuel A. ^[1]

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1. Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, United States
2. Department of Chemistry, College of Idaho, 2112 Cleveland Boulevard, Caldwell, Idaho 83605, United States
3. Spectra Solutions Inc., 1502 Providence Highway, Norwood, Massachusetts 02062-4643, United States
4. Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, United States; Washington State University, Department of Chemistry, Pullman, WA 99164, United States

Microfluidic devices are a growing field with significant potential for application to small scale processing of solutions. Much like large scale processing, fast, reliable, and cost effective means of monitoring the streams during processing are needed. Here we apply a novel Micro-Raman probe to the on-line monitoring of streams within a microfluidic device. For either macro or micro scale process monitoring via spectroscopic response, there is the danger of interfering or confounded bands obfuscating results. By utilizing chemometric analysis, a form of multivariate analysis, species can be accurately quantified in solution despite the presence of overlapping or confounded spectroscopic bands. This is demonstrated on solutions of HNO₃ and NaNO₃ within micro-flow and microfluidic devices.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE Office of Nuclear Energy (NE)
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1439670
• Report Number(s): PNNL-SA-126639; 453060037
• Journal Information: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 4 Vol. 90; ISSN 0003-2700
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: English