Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods

Journal Article · Mon Apr 02 04:00:00 EDT 2018 · Analytical and Bioanalytical Chemistry

DOI:https://doi.org/10.1007/s00216-018-0992-z· OSTI ID:1438980

Dixon, Holly M.; Scott, Richard P.; Holmes, Darrell; Calero, Lehyla; Kincl, Laurel D.; Waters, Katrina M.; Camann, David E.; Calafat, Antonia M.; Herbstman, Julie B.; Anderson, Kim A.

Currently there is a lack of inexpensive, easy-to-use technology to evaluate human exposure to environmental chemicals, including polycyclic aromatic hydrocarbons (PAHs). This is the first study in which silicone wristbands were deployed alongside other PAH exposure assessment methodologies. Wristbands were used within an established Columbia Center for Children’s Environmental Health birth cohort and compared to two traditional personal PAH exposure assessment methods: biological sampling with urine and active air monitoring with samplers (i.e. polyurethane foam (PUF) and filter) housed in backpacks. All samplers were deployed simultaneously on 22 pregnant women for 48-hours. Each woman provided one spot urine sample at the end of the 48-hour period. Sixty-two and 20 PAHs were quantified in the wristbands and PUF/filter, respectively; and eight hydroxy-PAH (OH-PAH) metabolites were quantified in the urine. PAHs in the PUF/filter and OH-PAHs correlate significantly for two of the eight comparisons (rs=0.53 and p=0.01; rs=0.44 and p=0.04). PAHs in the wristband and OH-PAHs correlate significantly for four of the eight comparisons; 1-OH-phenanthrene and 1-OH-pyrene strongly correlate with the parent PAHs in the wristband (rs=0.76 and p=<0.0001; rs=0.66 and p=0.0009). These results suggest wristbands are more closely associated with OH-PAHs in urine than active personal air monitoring methods.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1438980
• Report Number(s): PNNL-SA-123134; 453060036
• Journal Information: Analytical and Bioanalytical Chemistry, Journal Name: Analytical and Bioanalytical Chemistry Journal Issue: 13 Vol. 410; ISSN 1618-2642
• Publisher: Springer
• Country of Publication: United States
• Language: English