skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5'-phosphate in aspartate aminotransferase

Journal Article · · Journal of Biological Chemistry
; ; ; ; ;

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Science Foundation (NSF)
OSTI ID:
1438902
Journal Information:
Journal of Biological Chemistry, Vol. 292, Issue 14; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

References (39)

Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy journal January 2005
Effect of the damping function in dispersion corrected density functional theory journal March 2011
Serum Glutamic-Oxaloacetic Transaminase Activity journal August 1962
Use of 1 H− 15 N Heteronuclear Multiple-Quantum Coherence NMR Spectroscopy To Study the Active Site of Aspartate Aminotransferase † journal January 1997
Refinement and Comparisons of the Crystal Structures of Pig Cytosolic Aspartate Aminotransferase and Its Complex with 2-Methylaspartate journal July 1997
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal March 2011
Aspartate aminotransferase: An old dog teaches new tricks journal February 2014
Overview of the CCP 4 suite and current developments journal March 2011
Critical hydrogen bonds and protonation states of pyridoxal 5′-phosphate revealed by NMR journal November 2011
Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphate journal June 1992
Coupling of Functional Hydrogen Bonds in Pyridoxal-5‘-phosphate−Enzyme Model Systems Observed by Solid-State NMR Spectroscopy journal April 2007
Use of TLS parameters to model anisotropic displacements in macromolecular refinement journal January 2001
Coot model-building tools for molecular graphics journal November 2004
Crystal Structures of Aspartate Aminotransferase Reconstituted with 1-Deazapyridoxal 5′-Phosphate: Internal Aldimine and Stable l -Aspartate External Aldimine journal July 2011
Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions
  • Marenich, Aleksandr V.; Cramer, Christopher J.; Truhlar, Donald G.
  • The Journal of Physical Chemistry B, Vol. 113, Issue 18, p. 6378-6396 https://doi.org/10.1021/jp810292n
journal May 2009
Correlated proton motion in hydrogen bonded systems: tuning proton affinities journal January 2007
Pyridoxal 5′-phosphate: electrophilic catalyst extraordinaire journal October 2009
Mechanism of Formation of the Internal Aldimine in Pyridoxal 5′-Phosphate-Dependent Enzymes
  • Oliveira, Eduardo F.; Cerqueira, Nuno M. F. S. A.; Fernandes, Pedro A.
  • Journal of the American Chemical Society, Vol. 133, Issue 39 https://doi.org/10.1021/ja204229m
journal October 2011
A graphical user interface to the CCP 4 program suite journal June 2003
A genomic overview of pyridoxal-phosphate-dependent enzymes journal September 2003
The Low Barrier Hydrogen Bond in Enzymatic Catalysis journal October 1998
Investigation of crystalline enzyme—Substrate complexes of pyridoxal phosphate-dependent enzymes book January 1979
PHENIX : building new software for automated crystallographic structure determination journal October 2002
Transient-State Kinetics of the Reaction of Aspartate Aminotransferase with Aspartate at Low pH Reveals Dual Routes in the Enzyme−Substrate Association Process † journal November 1997
15 N Nuclear Magnetic Resonance Studies of Acid−Base Properties of Pyridoxal-5‘-Phosphate Aldimines in Aqueous Solution journal April 2007
NMR Localization of Protons in Critical Enzyme Hydrogen Bonds journal August 2007
Gateway ® recombinational cloning: a biological operating system journal April 2007
Role of the Pyridine Nitrogen in Pyridoxal 5′-Phosphate Catalysis: Activity of Three Classes of PLP Enzymes Reconstituted with Deazapyridoxal 5′-Phosphate journal September 2011
Theoretical study on the distribution of atomic charges in the Schiff bases of 3-hydroxypyridine-4-aldehyde and alanine. The effect of the protonation state of the pyridine and imine nitrogen atoms journal January 2009
Characterization of the apparent negative co-operativity induced in Escherichia coli aspartate aminotransferase by the replacement of Asp222 with alanine. Evidence for an extremely slow conformational change journal January 1994
NMR Studies of Protonation and Hydrogen Bond States of Internal Aldimines of Pyridoxal 5′-Phosphate Acid–Base in Alanine Racemase, Aspartate Aminotransferase, and Poly- l -lysine journal November 2013
The Reaction Catalyzed by Escherichia coli Aspartate Aminotransferase Has Multiple Partially Rate-Determining Steps, While That Catalyzed by the Y225F Mutant Is Dominated by Ketimine Hydrolysis † journal January 1996
NMR Studies of Coupled Low- and High-Barrier Hydrogen Bonds in Pyridoxal-5‘-phosphate Model Systems in Polar Solution journal April 2007
Accurate Coulomb-fitting basis sets for H to Rn journal January 2006
Reaction specificity in pyridoxal phosphate enzymes journal January 2005
A Hybrid QM/MM Simulation Study of Intramolecular Proton Transfer in the Pyridoxal 5′-Phosphate in the Active Site of Transaminase: Influence of Active Site Interaction on Proton Transfer journal September 2014
Functional roles of valine 37 and glycine 38 in the mobile loop of porcine cytosolic aspartate aminotransferase. journal November 1993
NMR observation of exchangeable protons of pyridoxal phosphate and histidine residues in cytosolic aspartate aminotransferase. journal September 1991
NMR studies of 1H resonances in the 10-18-ppm range for cytosolic aspartate aminotransferase. journal November 1994

Cited By (6)

Low‐Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad journal November 2019
Hyperconjugation promoted by hydrogen bonding between His98/His241 and a carboxyl group contributes to tyrosine decarboxylase catalysis journal January 2019
Bioinformatic analysis of the fold type I PLP ‐dependent enzymes reveals determinants of reaction specificity in l ‐threonine aldolase from Aeromonas jandaei journal May 2018
Investigations into the flexibility of the 3D structure and rigid backbone of quinoline by fluorine addition to enhance its blue emission journal January 2018
Low‐Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad journal September 2019
Dimerization misalignment in human glutamate-oxaloacetate transaminase variants is the primary factor for PLP release journal September 2018

Similar Records

Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5'-phosphate in aspartate aminotransferase
Journal Article · Thu Feb 23 00:00:00 EST 2017 · Journal of Biological Chemistry · OSTI ID:1438902
+3 more
Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5′-phosphate-dependent aminotransferase
Journal Article · Tue May 01 00:00:00 EDT 2007 · Acta Crystallographica. Section F · OSTI ID:1438902
+13 more
Pyridoxal 5'-phosphate dependent reactions: Analyzing the mechanism of aspartate aminotransferase
Journal Article · Sat Feb 01 00:00:00 EST 2020 · Methods in Enzymology · OSTI ID:1438902
+1 more

Related Subjects