Engineering Elastin-Like Polypeptide-Poly(ethylene glycol) Multiblock Physical Networks

Araújo, Andreia; Olsen, Bradley D.; Machado, Ana Vera

doi:10.1021/acs.biomac.7b01424

Title: Engineering Elastin-Like Polypeptide-Poly(ethylene glycol) Multiblock Physical Networks

Journal Article · Mon Dec 18 00:00:00 EST 2017 · Biomacromolecules

DOI:https://doi.org/10.1021/acs.biomac.7b01424· OSTI ID:1437484

Araújo, Andreia ^[1];

^[2];

^[1]

Univ. of Minho, Guimarães (Portugal)
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Hybrids of protein biopolymers and synthetic polymers are a promising new class of soft materials, as the advantages of each component can be complementary. A recombinant elastin-like polypeptide (ELP) was conjugated to poly(ethylene glycol) (PEG) by macromolecular coupling in solution to form multiblock ELP-PEG copolymers. The hydrated copolymer preserved the thermoresponsive properties from the ELP block and formed hydrogels with different transition temperatures depending on salt concentration. Small angle scattering indicates that the copolymer hydrogels form sphere-like aggregates with a “fuzzy” interface, while the films form a fractal network of nanoscale aggregates. Here, the use of solutions with different salt concentrations to prepare the hydrogels was found to influence the transition temperature, the mechanical properties, and the size of the nanoscale structure of the hydrogel without changing the secondary structure of the ELP. The salt variation and the addition of a plasticizer also affected the nanoscale structure and the mechanical characteristics of the films.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Science Foundation (NSF)

OSTI ID:: 1437484

Journal Information:: Biomacromolecules, Vol. 19, Issue 2; ISSN 1525-7797

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 9 works

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Title: Engineering Elastin-Like Polypeptide-Poly(ethylene glycol) Multiblock Physical Networks

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