A comparison of mesoporous silica nanoparticles and mesoporous organosilica nanoparticles as drug vehicles for cancer therapy

Journal Article · Sat May 12 00:00:00 EDT 2018 · Chemical Biology & Drug Design

DOI:https://doi.org/10.1111/cbdd.13309· OSTI ID:1437056

Yue, Juan ^[1]; Luo, Shi‐zhong ^[2]; Lu, Meng‐meng ^[3]; Shao, Dan ^[4]; Wang, Zheng ^[4]; Dong, Wen‐fei ^[4]

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1. The Key Laboratory of Functional Molecular Solids Anhui Laboratory of Molecular‐Based Materials Ministry of Education Center for Nano Science and Technology College of Chemistry and Materials Science Anhui Normal University Wuhu China, CAS Key Laboratory of Bio‐Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China
2. The Key Laboratory of Functional Molecular Solids Anhui Laboratory of Molecular‐Based Materials Ministry of Education Center for Nano Science and Technology College of Chemistry and Materials Science Anhui Normal University Wuhu China
3. Jiangsu Key Laboratory of Oral Disease Department of Oral Implantology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China
4. CAS Key Laboratory of Bio‐Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China

Mesoporous silica nanoparticles (MSNs) are promising drug carriers for use in cancer treatment owing to their excellent biocompatibility and drug‐loading capacity. However, MSN's incomplete drug release and toxic bioaccumulation phenomena limit their clinical application. Recently, researchers have presented redox responsive mesoporous organosilica nanoparticles containing disulfide (S–S) bridges (ss‐MONs). These nanoparticles retained their ability to undergo structural degradation and increased their local release activity when exposed to reducing agents. Disulfide‐based mesoporous organosilica nanoparticles offer researchers a better option for loading chemotherapeutic drugs due to their effective biodegradability through the reduction of glutathione. Although the potential of ss‐MONs in cancer theranostics has been studied, few researchers have systematically compared ss‐MONs with MSNs with regard to endocytosis, drug release, cytotoxicity, and therapeutic effect. In this work, ss‐MONs and MSNs with equal morphology and size were designed and used to payload doxorubicin hydrochloride (DOX) for liver cancer chemotherapy. The ss‐MONs showed considerable degradability in the presence of glutathione and performed comparably to MSNs on biocompatibility measures, including cytotoxicity and endocytosis, as well as in drug‐loading capacity. Notably, DOX‐loaded ss‐MONs exhibited higher intracellular drug release in cancer cells and better anticancer effects in comparison with DOX‐loaded MSNs. Hence, the ss‐MONs may be more desirable carriers for a highly efficient and safe treatment of cancer.

• Sponsoring Organization: USDOE
• OSTI ID: 1437056
• Journal Information: Chemical Biology & Drug Design, Journal Name: Chemical Biology & Drug Design Vol. 92 Journal Issue: 2; ISSN 1747-0277
• Publisher: Wiley-Blackwell
• Country of Publication: United Kingdom
• Language: English