Intracellular cellobiose metabolism and its applications in lignocellulose-based biorefineries

Parisutham, Vinuselvi; Chandran, Sathesh-Prabu; Mukhopadhyay, Aindrila; Lee, Sung Kuk; Keasling, Jay D.

doi:10.1016/j.biortech.2017.05.001

Intracellular cellobiose metabolism and its applications in lignocellulose-based biorefineries

Journal Article · Thu May 04 00:00:00 EDT 2017 · Bioresource Technology

DOI:https://doi.org/10.1016/j.biortech.2017.05.001· OSTI ID:1436614

Parisutham, Vinuselvi ^[1]; Chandran, Sathesh-Prabu ^[1]; Mukhopadhyay, Aindrila ^[2]; Lee, Sung Kuk ^[1]; Keasling, Jay D. ^[3]

Ulsan National Institute of Science and Technology (UNIST), Ulsan (Korea, Republic of)
Joint BioEnergy Inst., Emeryville, CA (United States)
Joint BioEnergy Inst., Emeryville, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Technical Univ. of Denmark, Horsholm (Denmark). Novo Nordisk Foundation Center for Biosustainability; Synthetic Biology Engineering Research Center (Synberc), Berkeley, CA (United States)

Complete hydrolysis of cellulose has been noted as a key characteristic of biomass technology due to the limitation of industrial production hosts to use cellodextrin, the partial hydrolysis product of cellulose. Cellobiose, a β-1,4-linked glucose dimer, is a major cellodextrin of the enzymatic hydrolysis (via endoglucanase and exoglucanase) of cellulose. Conversion of cellobiose to glucose is executed by β-glucosidase. The complete extracellular hydrolysis of celluloses has several critical barriers in biomass technology. An alternative bioengineering strategy to make the bioprocessing less challenging is to engineer microbes with the abilities to hydrolyze and assimilate the cellulosic-hydrolysate cellodextrin. Microorganisms engineered to metabolize cellobiose rather than the monomeric glucose can provide several advantages for lignocellulose-based biorefineries. This review describes the recent advances and challenges in engineering efficient intracellular cellobiose metabolism in industrial hosts. This review also describes the limitations of and future prospectives in engineering intracellular cellobiose metabolism.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1436614

Alternate ID(s):: OSTI ID: 1550532

Journal Information:: Bioresource Technology, Journal Name: Bioresource Technology Journal Issue: C Vol. 239; ISSN 0960-8524

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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