A convolutional neural network-based screening tool for X-ray serial crystallography
Journal Article
·
· Journal of Synchrotron Radiation (Online)
A new tool is introduced for screening macromolecular X-ray crystallography diffraction images produced at an X-ray free-electron laser light source. Based on a data-driven deep learning approach, the proposed tool executes a convolutional neural network to detect Bragg spots. Automatic image processing algorithms described can enable the classification of large data sets, acquired under realistic conditions consisting of noisy data with experimental artifacts. Outcomes are compared for different data regimes, including samples from multiple instruments and differing amounts of training data for neural network optimization.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- Grant/Contract Number:
- AC02-05CH11231; AC02-76SF00515
- OSTI ID:
- 1434392
- Alternate ID(s):
- OSTI ID: 1460313
- Journal Information:
- Journal of Synchrotron Radiation (Online), Journal Name: Journal of Synchrotron Radiation (Online) Vol. 25 Journal Issue: 3; ISSN 1600-5775
- Publisher:
- International Union of Crystallography (IUCr)Copyright Statement
- Country of Publication:
- Denmark
- Language:
- English
Cited by: 30 works
Citation information provided by
Web of Science
Web of Science
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