A narrow open tubular column for high efficiency liquid chromatographic separation

Chen, Huang; Yang, Yu; Qiao, Zhenzhen; Xiang, Piliang; Ren, Jiangtao; Meng, Yunzhu; Zhang, Kaiqi; Juan Lu, Joann; Liu, Shaorong

doi:10.1039/C7AN02065A

Title: A narrow open tubular column for high efficiency liquid chromatographic separation

Journal Article · Mon Apr 30 00:00:00 EDT 2018 · Analyst

DOI:https://doi.org/10.1039/C7AN02065A· OSTI ID:1434094

Chen, Huang ^[1]; Yang, Yu ^[1]; Qiao, Zhenzhen ^[2]; Xiang, Piliang ^[1]; Ren, Jiangtao ^[1]; Meng, Yunzhu ^[1]; Zhang, Kaiqi ^[1]; Juan Lu, Joann ^[1];

^[1]

Department of Chemistry and Biochemistry, University of Oklahoma, Norman, USA
Department of Microbiology and Plant Biology, University of Oklahoma, Norman, USA

We report a great feature of open tubular liquid chromatography when it is run using an extremely narrow ( e.g. , 2 μm inner diameter) open tubular column: more than 10 million plates per meter can be achieved in less than 10 min and under an elution pressure of ca. 20 bar.

View Accepted Manuscript (Publisher)

Cite

Export

Save

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0006351

OSTI ID:: 1434094

Journal Information:: Analyst, Journal Name: Analyst Vol. 143 Journal Issue: 9; ISSN 0003-2654

Publisher:: Royal Society of Chemistry (RSC)Copyright Statement

Country of Publication:: United Kingdom

Language:: English

Citation Metrics:

Cited by: 15 works

Citation information provided by
Web of Science

References (12)

Theoretical Aspects of LC with Packed and Open Small-Bore Columns Knox, J. H. Journal of Chromatographic Science, Vol. 18, Issue 9 https://doi.org/10.1093/chromsci/18.9.453	journal	September 1980
Conventional packed columns vs. packed or open tubular microcolumns in liquid chromatography Guiochon, Georges. Analytical Chemistry, Vol. 53, Issue 9 https://doi.org/10.1021/ac00232a006	journal	August 1981
Confocal laser-induced fluorescence detector for narrow capillary system with yoctomole limit of detection Weaver, Mitchell T.; Lynch, Kyle B.; Zhu, Zaifang Talanta, Vol. 165 https://doi.org/10.1016/j.talanta.2016.12.056	journal	April 2017
Microcolumn separations and the analysis of single cells Kennedy, R.; Oates, M.; Cooper, B. Science, Vol. 246, Issue 4926 https://doi.org/10.1126/science.2675314	journal	October 1989
Separation of intact proteins on porous layer open tubular (PLOT) columns Rogeberg, Magnus; Wilson, Steven Ray; Greibrokk, Tyge Journal of Chromatography A, Vol. 1217, Issue 17 https://doi.org/10.1016/j.chroma.2010.02.025	journal	April 2010
Kinetic optimization of straight open-tubular liquid chromatography Knox, John H.; Gilbert, Mary T. Journal of Chromatography A, Vol. 186 https://doi.org/10.1016/S0021-9673(00)95263-4	journal	December 1979
Submicrometer Particles and Slip Flow in Liquid Chromatography Rogers, Benjamin A.; Wu, Zhen; Wei, Bingchuan Analytical Chemistry, Vol. 87, Issue 5 https://doi.org/10.1021/ac504683d	journal	February 2015
Electrochromatography in chemically modified etched fused-silica capillaries Pesek, Joseph J.; Matyska, Maria T. Journal of Chromatography A, Vol. 736, Issue 1-2 https://doi.org/10.1016/0021-9673(95)01320-2	journal	June 1996
Separation by flow (hydrodynamic chromatography) of macromolecules performed in open microcapillary tubes Tijssen, R.; Bleumer, J. P. A.; Van Kreveld, M. E. Journal of Chromatography A, Vol. 260 https://doi.org/10.1016/0021-9673(83)80038-7	journal	January 1983
Ultratrace LC/MS Proteomic Analysis Using 10-μm-i.d. Porous Layer Open Tubular Poly(styrene−divinylbenzene) Capillary Columns Yue, Guihua; Luo, Quanzhou; Zhang, Jian Analytical Chemistry, Vol. 79, Issue 3 https://doi.org/10.1021/ac061411m	journal	February 2007
Liquid chromatography in open-tubular columns Jorgenson, James W.; Guthrie, Edward J. Journal of Chromatography A, Vol. 255 https://doi.org/10.1016/S0021-9673(01)88293-5	journal	January 1983
Slip Flow in Colloidal Crystals for Ultraefficient Chromatography Wei, Bingchuan; Rogers, Benjamin J.; Wirth, Mary J. Journal of the American Chemical Society, Vol. 134, Issue 26 https://doi.org/10.1021/ja304177m	journal	June 2012

Similar Records

A narrow open tubular column for high efficiency liquid chromatographic separation

Journal Article · Mon Jan 01 00:00:00 EST 2018 · Analyst · OSTI ID:1434094

Chen, Huang; Yang, Yu; Qiao, Zhenzhen; +6 more

Neat and admixed mesomorphic polysiloxane stationary phases for open-tubular column gas chromatography

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Anal. Chem.; (United States) · OSTI ID:1434094

Janini, G M; Muschik, G M; Issaq, H J; +1 more

Narrow, Open, Tubular Column for Ultrahigh-Efficiency Liquid-Chromatographic Separation under Elution Pressure of Less than 50 bar

Journal Article · Fri Aug 17 00:00:00 EDT 2018 · Analytical Chemistry · OSTI ID:1434094

Yang, Yu; Chen, Huang; Beckner, Matthew A.; +4 more

Title: A narrow open tubular column for high efficiency liquid chromatographic separation

Citation Formats

References (12)

Similar Records

Related Subjects