Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold

Teplyakov, Alexey; Obmolova, Galina; Luo, Jinquan; Gilliland, Gary L.

doi:10.1002/prot.25485

Title: Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold

Journal Article · Sat Mar 10 00:00:00 EST 2018 · Proteins

DOI:https://doi.org/10.1002/prot.25485· OSTI ID:1433717

^[1]; Obmolova, Galina ^[1]; Luo, Jinquan ^[1]; Gilliland, Gary L. ^[1]

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: INDUSTRY

OSTI ID:: 1433717

Journal Information:: Proteins, Vol. 86, Issue 5; ISSN 0887-3585

Publisher:: Wiley

Country of Publication:: United States

Language:: ENGLISH

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Role of CD19 Signal Transduction in B Cell Biology Carter, Robert H.; Wang, Yue; Brooks, Stephen Immunologic Research, Vol. 26, Issue 1-3 https://doi.org/10.1385/IR:26:1-3:045	journal	January 2002
Canonical structures for the hypervariable regions of immunoglobulins Chothia, Cyrus; Lesk, Arthur M. Journal of Molecular Biology, Vol. 196, Issue 4 https://doi.org/10.1016/0022-2836(87)90412-8	journal	August 1987
TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy Grada, Zakaria; Hegde, Meenakshi; Byrd, Tiara Molecular Therapy - Nucleic Acids, Vol. 2 https://doi.org/10.1038/mtna.2013.32	journal	January 2013
Structural diversity in a human antibody germline library Teplyakov, Alexey; Obmolova, Galina; Malia, Thomas J. mAbs, Vol. 8, Issue 6 https://doi.org/10.1080/19420862.2016.1190060	journal	May 2016
CD19, from bench to bedside Li, Xinchen; Ding, Ying; Zi, Mengting Immunology Letters, Vol. 183 https://doi.org/10.1016/j.imlet.2017.01.010	journal	March 2017
Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma Nicholson, Ian C.; Lenton, Kelly A.; Little, Debbie J. Molecular Immunology, Vol. 34, Issue 16-17 https://doi.org/10.1016/S0161-5890(97)00144-2	journal	November 1997
An Antibody-Deficiency Syndrome Due to Mutations in the CD19 Gene van Zelm, Menno C.; Reisli, Ismail; van der Burg, Mirjam New England Journal of Medicine, Vol. 354, Issue 18 https://doi.org/10.1056/NEJMoa051568	journal	May 2006
B cell–directed therapies for autoimmune disease and correlates of disease response and relapse Levesque, Marc C.; St. Clair, E. William Journal of Allergy and Clinical Immunology, Vol. 121, Issue 1 https://doi.org/10.1016/j.jaci.2007.11.030	journal	January 2008
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Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children’s Oncology Group Meany, Holly J.; Seibel, Nita L.; Krailo, Mark Journal of Immunotherapy, Vol. 38, Issue 7 https://doi.org/10.1097/CJI.0000000000000088	journal	January 2015
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