Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

Georgiev, Hristo; Ravens, Inga; Papadogianni, Georgia; Halle, Stephan; Malissen, Bernard; Loots, Gabriela G.; Förster, Reinhold; Bernhardt, Günter

doi:10.3389/fimmu.2018.00714

Title: Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

Journal Article · Mon Apr 09 00:00:00 EDT 2018 · Frontiers in Immunology

DOI:https://doi.org/10.3389/fimmu.2018.00714· OSTI ID:1432391

Georgiev, Hristo; Ravens, Inga; Papadogianni, Georgia; Halle, Stephan; Malissen, Bernard; Loots, Gabriela G.; Förster, Reinhold; Bernhardt, Günter

Follicular helper (TFH) and regulatory (TFR) cells are essential players in managing germinal center (GC) reactions that accomplish effective humoral immune responses. Transcriptome analyses were done comparing gene regulation of TFH and TFR cells isolated from Peyer’s Patches (PP) and immunized peripheral lymph nodes (pLNs) revealing many regulatory patterns common to all follicular cells. Yet, in contrast to TFH cells, the upregulation or downregulation of many genes was attenuated substantially in pLN TFR cells when compared to those of PP. Additionally, PP but not pLN TFR cells were largely unresponsive to IL2 and expressed Il4 as well as Il21. Together with fundamental differences in gene expression that were found between cells of both compartments this emphasizes specific adaptations of follicular T cell functions to their micro-milieu. Furthermore, although GL7 expression distinguishes matured follicular T cells, GL7⁺ as well as GL7^– cells are present in the GC.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1432391

Alternate ID(s):: OSTI ID: 1527289

Report Number(s):: LLNL-JRNL-741132; 714

Journal Information:: Frontiers in Immunology, Journal Name: Frontiers in Immunology Vol. 9; ISSN 1664-3224

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

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Cited by: 17 works

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