Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

Journal Article · Mon Aug 11 00:00:00 EDT 2014 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/jm500694p· OSTI ID:1427830

Lee, Kin Sing Stephen ^[1]; Liu, Jun-Yan ^[1]; Wagner, Karen M. ^[1]; Pakhomova, Svetlana ^[2]; Dong, Hua ^[1]; Morisseau, Christophe ^[1]; Fu, Samuel H. ^[1]; Yang, Jun ^[1]; Wang, Peng ^[3]; Ulu, Arzu ^[1]; Mate, Christina A. ^[1]; Nguyen, Long V. ^[1]; Hwang, Sung Hee ^[1]; Edin, Matthew L. ^[4]; Mara, Alexandria A. ^[4]; Wulff, Heike ^[5]; Newcomer, Marcia E. ^[2]; Zeldin, Darryl C. ^[4]; Hammock, Bruce D. ^[1]

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1. Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, California 95616, United States
2. Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, United States
3. Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, California 95616, United States; Department of Applied Chemistry, China Agricultural University, Beijing 100193, People’s Republic of China
4. Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States
5. Department of Pharmacology, University of California Davis, Davis, California 95616, United States

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: NIHOTHER
• OSTI ID: 1427830
• Journal Information: Journal of Medicinal Chemistry, Vol. 57, Issue 16; ISSN 0022-2623
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: ENGLISH