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Title: Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex

Abstract

Using the electrostatic complex of G4 poly(amidoamine) (PAMAM) dendrimer with an amphiphilic surfactant as a model system, contrast variation small angle neutron scattering (SANS) is implemented to resolve the key structural characteristics of dendrimer-based guest–host system. Quantifications of the radial distributions of the scattering length density and the hydration level within the complex molecule reveal that the surfactant is embedded in the peripheral region of dendrimer and the steric crowding in this region increases the backfolding of the dendritic segments, thereby reducing the hydration level throughout the complex molecule. Here, the insights into the spatial location of the guest molecules as well as the perturbations of dendrimer conformation and hydration level deduced here are crucial for the delicate design of dendrimer-based guest–host system for biomedical applications.

Authors:
 [1];  [1];  [2];  [3]
  1. National Tsing Hua Univ., Hsinchu (Taiwan). Dept. of Chemical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Science (CNMS)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); National Tsing Hua Univ., Hsinchu (Taiwan)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Ministry of Science and Technology (MOST) (Taiwan)
OSTI Identifier:
1427604
DOE Contract Number:  
AC05-00OR22725; MOST 102-2221-E-007-136-MY3; MOST 105-2221-E-007-137-MY3
Resource Type:
Journal Article
Journal Name:
ACS Macro Letters
Additional Journal Information:
Journal Volume: 5; Journal Issue: 9; Journal ID: ISSN 2161-1653
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Liu, Chih-Ying, Chen, Hsin-Lung, Do, Changwoo, and Hong, Kunlun. Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex. United States: N. p., 2016. Web. doi:10.1021/acsmacrolett.6b00526.
Liu, Chih-Ying, Chen, Hsin-Lung, Do, Changwoo, & Hong, Kunlun. Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex. United States. https://doi.org/10.1021/acsmacrolett.6b00526
Liu, Chih-Ying, Chen, Hsin-Lung, Do, Changwoo, and Hong, Kunlun. Tue . "Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex". United States. https://doi.org/10.1021/acsmacrolett.6b00526.
@article{osti_1427604,
title = {Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex},
author = {Liu, Chih-Ying and Chen, Hsin-Lung and Do, Changwoo and Hong, Kunlun},
abstractNote = {Using the electrostatic complex of G4 poly(amidoamine) (PAMAM) dendrimer with an amphiphilic surfactant as a model system, contrast variation small angle neutron scattering (SANS) is implemented to resolve the key structural characteristics of dendrimer-based guest–host system. Quantifications of the radial distributions of the scattering length density and the hydration level within the complex molecule reveal that the surfactant is embedded in the peripheral region of dendrimer and the steric crowding in this region increases the backfolding of the dendritic segments, thereby reducing the hydration level throughout the complex molecule. Here, the insights into the spatial location of the guest molecules as well as the perturbations of dendrimer conformation and hydration level deduced here are crucial for the delicate design of dendrimer-based guest–host system for biomedical applications.},
doi = {10.1021/acsmacrolett.6b00526},
url = {https://www.osti.gov/biblio/1427604}, journal = {ACS Macro Letters},
issn = {2161-1653},
number = 9,
volume = 5,
place = {United States},
year = {2016},
month = {8}
}