Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

Hummel, Jessica M.; Madeen, Erin P.; Siddens, Lisbeth K.; Uesugi, Sandra L.; McQuistan, Tammie; Anderson, Kim A.; Turteltaub, Kenneth W.; Ognibene, Ted J.; Bench, Graham; Krueger, Sharon K.; Harris, Stuart; Smith, Jordan; Tilton, Susan C.; Baird, William M.; Williams, David E.

doi:10.1016/J.FCT.2018.03.003

Pharmacokinetics of [¹⁴C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

Journal Article · Thu Mar 01 00:00:00 EST 2018 · Food and Chemical Toxicology

DOI:https://doi.org/10.1016/J.FCT.2018.03.003· OSTI ID:1425498

Hummel, Jessica M. ^[1]; Madeen, Erin P. ^[2]; Siddens, Lisbeth K. ^[3]; Uesugi, Sandra L. ^[4]; McQuistan, Tammie ^[4]; Anderson, Kim A. ^[2]; Turteltaub, Kenneth W. ^[5]; Ognibene, Ted J. ^[6]; Bench, Graham ^[6]; Krueger, Sharon K. ^[4]; Harris, Stuart ^[7]; Smith, Jordan ^[8]; Tilton, Susan C. ^[2]; Baird, William M. ^[2]; Williams, David E. ^[3]

Oregon State Univ., Corvallis, OR (United States). Dept. of Nutrition and Dietetics, and Superfund Research Program
Oregon State Univ., Corvallis, OR (United States). Superfund Research Program; Oregon State Univ., Corvallis, OR (United States). Dept. of Environmental and Molecular Toxicology
Oregon State Univ., Corvallis, OR (United States). Superfund Research Program; Oregon State Univ., Corvallis, OR (United States). Dept. of Environmental and Molecular Toxicology; Oregon State Univ., Corvallis, OR (United States). Linus Pauling Inst.
Oregon State Univ., Corvallis, OR (United States). Linus Pauling Inst.
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Biosciences and Biotechnology Division
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Center for Accelerator Mass Spectrometry
Confederated Tribes of the Umatilla Indian Reservation, Pendelton, OR (United States). Nixyaawii Governance Center
Oregon State Univ., Corvallis, OR (United States). Superfund Research Program; Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Chemical Biology and Exposure Science

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of complex PAH mixtures. PAH relative potency factors (RPFs, BaP=1) are determined from high dose animal data. Here we employed accelerator mass spectrometry (AMS) to determine pharmacokinetics of [¹⁴C]-BaP in humans following dosing with 46 ng (an order of magnitude lower than human dietary daily exposure and million-fold lower than animal cancer models). To assess the impact of co-administration of food with a complex PAH mixture, humans were dosed with 46 ng of [¹⁴C]-BaP with or without smoked salmon. Subjects were asked to avoid high BaP-containing diets and a 3-day dietary questionnaire given to assess dietary exposure prior to dosing and three days post-dosing with [¹⁴C]-BaP. Co-administration of smoked salmon, containing a complex mixture of PAHs with an RPF of 460 ng BaP_eq, reduced and delayed absorption. Administration of canned commercial salmon, containing very low amounts of PAHs, showed the impacts on pharmacokinetics were not due to high amounts of PAHs but rather a food matrix effect.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC05-76RL01830; AC52-07NA27344

OSTI ID:: 1425498

Alternate ID(s):: OSTI ID: 1503550
OSTI ID: 1513160

Report Number(s):: LLNL-JRNL--745576; PNNL-SA--132485; PII: S027869151830142X

Journal Information:: Food and Chemical Toxicology, Journal Name: Food and Chemical Toxicology Vol. 115; ISSN 0278-6915

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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