Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

Policicchio, Benjamin Bruno; Sette, Paola; Xu, Cuiling; Haret-Richter, George; Dunsmore, Tammy; Pandrea, Ivona; Ribeiro, Ruy Miguel; Apetrei, Cristian

doi:10.1371/journal.pone.0190908

Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

Journal Article · Wed Feb 21 00:00:00 EST 2018 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0190908· OSTI ID:1423983

Policicchio, Benjamin Bruno ^[1]; Sette, Paola ^[1]; Xu, Cuiling ^[1]; Haret-Richter, George ^[1]; Dunsmore, Tammy ^[1]; Pandrea, Ivona ^[1]; ^[2]; Apetrei, Cristian ^[1]

Univ. of Pittsburgh, PA (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. de Lisbo, Lisboa (Portugal)

Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL)

Sponsoring Organization:: National Institutes of Health; USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1423983

Report Number(s):: LA-UR-18-20169

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 2 Vol. 13; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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