Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

O’Hara, Matthew J.; Murray, Nathaniel J.; Carter, Jennifer C.; Morrison, Samuel S.

doi:10.1016/j.chroma.2018.02.053

Optimized anion exchange column isolation of zirconium-89 (⁸⁹Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Journal Article · Fri Feb 23 23:00:00 EST 2018 · Journal of Chromatography

DOI:https://doi.org/10.1016/j.chroma.2018.02.053· OSTI ID:1422509

^[1]; Murray, Nathaniel J. ^[1]; Carter, Jennifer C. ^[1]; Morrison, Samuel S. ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Nuclear Sciences Division

Zirconium-89 (⁸⁹Zr), produced by the (p, n) reaction from naturally monoisotopic yttrium (^natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new ⁸⁹Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>10⁵) and has been shown to remove Fe, an abundant contaminant in Y foils, from the ⁸⁹Zr elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the 89Zr present in the foils. The anion exchange column method described here is intended to be the first ⁸⁹Zr isolation stage in a dual-column purification process.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26); National Institutes of Health (NIH)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1422509

Alternate ID(s):: OSTI ID: 1427914
OSTI ID: 1593331

Report Number(s):: PNNL-SA--116062; PII: S0021967318302371

Journal Information:: Journal of Chromatography, Journal Name: Journal of Chromatography Vol. 1545; ISSN 0021-9673

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (49)

Extraction of zirconium(IV) from HCl solutions by mixtures of Aliquat-336 and Alamine-336 with TBP Mishra, P. K.; Chakravortty, V.; Dash, K. C. Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 134, Issue 2 https://doi.org/10.1007/BF02278262	journal	December 1989
Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcinoma Cheal, Sarah M.; Punzalan, Blesida; Doran, Michael G. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, Issue 5 https://doi.org/10.1007/s00259-013-2679-1	journal	March 2014
Tumour targeting and radiation dose of radioimmunotherapy with 90Y-rituximab in CD20+ B-cell lymphoma as predicted by 89Zr-rituximab immuno-PET: impact of preloading with unlabelled rituximab Muylle, Kristoff; Flamen, Patrick; Vugts, Danielle J. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 42, Issue 8 https://doi.org/10.1007/s00259-015-3025-6	journal	March 2015
A comparative study on the separation of radiozirconium via ion-exchange and solvent extraction techniques, with particular reference to the production of 88Zr and 89Zr in proton induced reactions on yttrium Kandil, S. A.; Scholten, B.; Saleh, Z. A. Journal of Radioanalytical and Nuclear Chemistry, Vol. 274, Issue 1 https://doi.org/10.1007/s10967-006-6892-2	journal	October 2007
Production of 88,89Zr by proton induced activation of natY and separation by SLX and LLX Dutta, Binita; Maiti, Moumita; Lahiri, Susanta Journal of Radioanalytical and Nuclear Chemistry, Vol. 281, Issue 3 https://doi.org/10.1007/s10967-009-0051-5	journal	June 2009
Stability constants for complexes of the siderophore desferrioxamine B with selected heavy metal cations Hernlem, Bradley J.; Vane, Leland M.; Sayles, Gregory D. Inorganica Chimica Acta, Vol. 244, Issue 2 https://doi.org/10.1016/0020-1693(95)04780-8	journal	March 1996
Production of no-carrier-added zirconium-89 for positron emission tomography Zweit, J.; Downey, S.; Sharma, H. L. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 42, Issue 2 https://doi.org/10.1016/0883-2889(91)90074-B	journal	January 1991
Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter Meijs, Wilma E.; Herscheid, Jacobus D. M.; Haisma, Hidde J. Applied Radiation and Isotopes, Vol. 45, Issue 12 https://doi.org/10.1016/0969-8043(94)90029-9	journal	December 1994
Ion exchange in aqueous and in aqueous-organic solvents Kim, J. I.; Lagally, H.; Born, H. -J. Analytica Chimica Acta, Vol. 64, Issue 1 https://doi.org/10.1016/S0003-2670(00)86889-0	journal	March 1973
Behaviour of Zr, Hf, Nb, Ta and Pa on macroporous anion exchanger in chloride–fluoride media Trubert, D.; Monroy Guzman, F.; Le Naour, C. Analytica Chimica Acta, Vol. 374, Issue 2-3 https://doi.org/10.1016/S0003-2670(98)00464-4	journal	November 1998
Ion exchange procedures Nelson, Frederick; Murase, Takeo; Kraus, Kurt A. Journal of Chromatography A, Vol. 13 https://doi.org/10.1016/S0021-9673(01)95146-5	journal	January 1964
Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT Walther, Martin; Gebhardt, Peter; Grosse-Gehling, Philipp Applied Radiation and Isotopes, Vol. 69, Issue 6 https://doi.org/10.1016/j.apradiso.2011.02.040	journal	June 2011
Cyclotron production and radiochemical purification of 88,89Zr via α-particle induced reactions on natural strontium Ivanov, P. I.; Jerome, S. M.; Bozhikov, G. A. Applied Radiation and Isotopes, Vol. 90 https://doi.org/10.1016/j.apradiso.2014.04.018	journal	August 2014
Semi-automated production of 89 Zr-oxalate/ 89 Zr-chloride and the potential of 89 Zr-chloride in radiopharmaceutical compounding Lin, Mai; Mukhopadhyay, Uday; Waligorski, Gregory J. Applied Radiation and Isotopes, Vol. 107 https://doi.org/10.1016/j.apradiso.2015.11.016	journal	January 2016
A simple and convenient method for production of 89Zr with high purity Tang, Yu; Li, Shuntao; Yang, Yuanyou Applied Radiation and Isotopes, Vol. 118 https://doi.org/10.1016/j.apradiso.2016.09.024	journal	December 2016
A simple thick target for production of 89Zr using an 11 MeV cyclotron Link, Jeanne M.; Krohn, Kenneth A.; O'Hara, Matthew J. Applied Radiation and Isotopes, Vol. 122 https://doi.org/10.1016/j.apradiso.2017.01.037	journal	April 2017
Standardisation and half-life of 89 Zr García-Toraño, E.; Peyrés, V.; Roteta, M. Applied Radiation and Isotopes, Vol. 134 https://doi.org/10.1016/j.apradiso.2017.10.033	journal	April 2018
Quantum mechanical investigation of aqueous desferrioxamine B metal complexes: Trends in structure, binding, and infrared spectroscopy Kruft, Bonnie I.; Harrington, James M.; Duckworth, Owen W. Journal of Inorganic Biochemistry, Vol. 129 https://doi.org/10.1016/j.jinorgbio.2013.08.008	journal	December 2013
Standardized methods for the production of high specific-activity zirconium-89 Holland, Jason P.; Sheh, Yiauchung; Lewis, Jason S. Nuclear Medicine and Biology, Vol. 36, Issue 7 https://doi.org/10.1016/j.nucmedbio.2009.05.007	journal	October 2009
PET imaging with 89Zr: From radiochemistry to the clinic Deri, Melissa A.; Zeglis, Brian M.; Francesconi, Lynn C. Nuclear Medicine and Biology, Vol. 40, Issue 1 https://doi.org/10.1016/j.nucmedbio.2012.08.004	journal	January 2013
Production of Zr-89 using sputtered yttrium coin targets Queern, Stacy Lee; Aweda, Tolulope Aramide; Massicano, Adriana Vidal Fernandes Nuclear Medicine and Biology, Vol. 50 https://doi.org/10.1016/j.nucmedbio.2017.03.004	journal	July 2017
Distribution coefficients and ion exchange behavior of 46 elements with a macroreticular cation exchange resin in hydrochloric acid Strelow, F. W. E. Analytical Chemistry, Vol. 56, Issue 6 https://doi.org/10.1021/ac00270a045	journal	May 1984
⁸⁹ Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art ⁸⁹ Zr Radiochemistry Heskamp, Sandra; Raavé, René; Boerman, Otto Bioconjugate Chemistry, Vol. 28, Issue 9 https://doi.org/10.1021/acs.bioconjchem.7b00325	journal	August 2017
Ti(IV) and the Siderophore Desferrioxamine B: A Tight Complex Has Biological and Environmental Implications Jones, Kayleigh E.; Batchler, Kathleen L.; Zalouk, Célia Inorganic Chemistry, Vol. 56, Issue 3 https://doi.org/10.1021/acs.inorgchem.6b02399	journal	January 2017
Radioimmunoimaging with Longer-Lived Positron-Emitting Radionuclides: Potentials and Challenges Nayak, Tapan K.; Brechbiel, Martin W. Bioconjugate Chemistry, Vol. 20, Issue 5 https://doi.org/10.1021/bc800299f	journal	May 2009
Anion Exchange Studies. I. Separation of Zirconium and Niobium in HCl-HF Mixtures ¹ Kraus, Kurt A.; Moore, George E. Journal of the American Chemical Society, Vol. 73, Issue 1 https://doi.org/10.1021/ja01145a003	journal	January 1951
ADSORPTION OF IRON BY ANION EXCHANGE RESINS FROM HYDROCHLORIC ACID SOLUTIONS ¹ Moore, George E.; Kraus, Kurt A. Journal of the American Chemical Society, Vol. 72, Issue 12 https://doi.org/10.1021/ja01168a549	journal	December 1950
Noninvasive Imaging of PSMA in Prostate Tumors with ⁸⁹ Zr-Labeled huJ591 Engineered Antibody Fragments: The Faster Alternatives Viola-Villegas, Nerissa Therese; Sevak, Kuntal K.; Carlin, Sean D. Molecular Pharmaceutics, Vol. 11, Issue 11 https://doi.org/10.1021/mp500164r	journal	April 2014
Kiss, Tamas; Farkas, Etelka Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, Vol. 32, Issue 2/3, p. 385-403 https://doi.org/10.1023/A:1008046330815	journal	November 1998
The Next Generation of Positron Emission Tomography Radiopharmaceuticals in Oncology Rice, Samuel L.; Roney, Celeste A.; Daumar, Pierre Seminars in Nuclear Medicine, Vol. 41, Issue 4 https://doi.org/10.1053/j.semnuclmed.2011.02.002	journal	July 2011
Zirconium and Hafnium Separation, Part 2. Solid/Liquid Extraction in Hydrochloric Acid Aqueous Solution with Anion Exchange Resins Poriel, L.; Pellet‐Rostaing, S.; Lamotte, V. Separation Science and Technology, Vol. 41, Issue 12 https://doi.org/10.1080/01496390600725711	journal	September 2006
Zirconium and Hafnium Separation, Part 1. Liquid/Liquid Extraction in Hydrochloric Acid Aqueous Solution with Aliquat 336 Poriel, L.; Favre‐Réguillon, A.; Pellet‐Rostaing, S. Separation Science and Technology, Vol. 41, Issue 9 https://doi.org/10.1080/01496390600725802	journal	July 2006
Measurements and a direct-reaction – plus – Hauser-Feshbach analysis of Y 89 ( p , n ) 89 Zr, Y 89 ( p ,2 n ) 88 , and Y 89 ( p , pn ) 88 Y reactions up to 40 MeV Mustafa, M. G.; West, H. I.; O’Brien, H. Physical Review C, Vol. 38, Issue 4 https://doi.org/10.1103/PhysRevC.38.1624	journal	October 1988
Oxidation of hydrogen chloride with hydrogen peroxide in aqueous solution Skudaev, V. I.; Solomonov, A. B.; Morozovskii, A. I. Russian Journal of Applied Chemistry, Vol. 81, Issue 1 https://doi.org/10.1134/S1070427208010035	journal	January 2008
Zirconium-89 Labeled Antibodies: A New Tool for Molecular Imaging in Cancer Patients van de Watering, Floor C. J.; Rijpkema, Mark; Perk, Lars BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/203601	journal	January 2014
89Zr-trastuzumab and 89Zr-bevacizumab PET to Evaluate the Effect of the HSP90 Inhibitor NVP-AUY922 in Metastatic Breast Cancer Patients Gaykema, S. B. M.; Schroder, C. P.; Vitfell-Rasmussen, J. Clinical Cancer Research, Vol. 20, Issue 15 https://doi.org/10.1158/1078-0432.CCR-14-0491	journal	July 2014
Proton induced reactions on 89Y with particular reference to the production of the medically interesting radionuclide 89Zr Omara, H. M.; Hassan, K. F.; Kandil, S. A. Radiochimica Acta, Vol. 97, Issue 9 https://doi.org/10.1524/ract.2009.1645	journal	January 2009
Some experimental studies on ⁸⁹ Zr production Ciarmatori, A.; Cicoria, G.; Pancaldi, D. ract, Vol. 99, Issue 10 https://doi.org/10.1524/ract.2011.1822	journal	January 2011
Immuno-PET: A Navigator in Monoclonal Antibody Development and Applications van Dongen, G. A. M. S.; Visser, G. W. M.; Lub-de Hooge, M. N. The Oncologist, Vol. 12, Issue 12 https://doi.org/10.1634/theoncologist.12-12-1379	journal	December 2007
89Zr-cetuximab PET imaging in patients with advanced colorectal cancer Menke-van der Houven van Oordt, Catharina Willemien; Gootjes, Elske C.; Huisman, Marc C. Oncotarget, Vol. 6, Issue 30 https://doi.org/10.18632/oncotarget.4672	journal	July 2015
89Zr Radiochemistry for Positron Emission Tomography W. Severin, Gregory; W. Engle, Jonathan; E. Barnhart, Todd Medicinal Chemistry, Vol. 7, Issue 5 https://doi.org/10.2174/157340611796799186	journal	September 2011
PET Tracers Based on Zirconium-89 Zhang, Yin; Hong, Hao; Cai, Weibo Current Radiopharmaceuticalse, Vol. 4, Issue 2 https://doi.org/10.2174/1874471011104020131	journal	April 2011
Unconventional Nuclides for Radiopharmaceuticals Holland, Jason P.; Williamson, Matthew J.; Lewis, Jason S. Molecular Imaging, Vol. 9, Issue 1 https://doi.org/10.2310/7290.2010.00008	journal	January 2010
Review on Production of 89Zr in a Medical Cyclotron for PET Radiopharmaceuticals Kasbollah, A.; Eu, P.; Cowell, S. Journal of Nuclear Medicine Technology, Vol. 41, Issue 1 https://doi.org/10.2967/jnmt.112.111377	journal	January 2013
Glypican-3-Targeting F(ab')2 for 89Zr PET of Hepatocellular Carcinoma Sham, J. G.; Kievit, F. M.; Grierson, J. R. Journal of Nuclear Medicine, Vol. 55, Issue 12 https://doi.org/10.2967/jnumed.114.145102	journal	October 2014
Immuno-Positron Emission Tomography with Zirconium-89-Labeled Monoclonal Antibodies in Oncology: What Can We Learn from Initial Clinical Trials? Jauw, Yvonne W. S.; Menke-van der Houven van Oordt, C. Willemien; Hoekstra, Otto S. Frontiers in Pharmacology, Vol. 7 https://doi.org/10.3389/fphar.2016.00131	journal	May 2016
Routine Production of 89Zr Using an Automated Module Wooten, A.; Madrid, Evelyn; Schweitzer, Gordon Applied Sciences, Vol. 3, Issue 3 https://doi.org/10.3390/app3030593	journal	July 2013
The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86 Ikotun, Oluwatayo F.; Lapi, Suzanne E. Future Medicinal Chemistry, Vol. 3, Issue 5 https://doi.org/10.4155/fmc.11.14	journal	April 2011
Cyclotron production of 89Zr: A potent radionuclide for positron emission tomography No authors listed International Journal of the Physical Sciences, Vol. 7, Issue 9 https://doi.org/10.5897/IJPS11.1394	journal	February 2012

Cited By (2)

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets O’Hara, Matthew J.; Krzysko, Anthony J.; Hamlin, Donald K. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-56272-7	journal	December 2019
Radiometals for imaging and theranostics, current production, and future perspectives Mikolajczak, Renata; van der Meulen, Nicholas P.; Lapi, Suzanne E. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, Issue 10 https://doi.org/10.1002/jlcr.3770	journal	July 2019

Similar Records

Optimized anion exchange column isolation of zirconium-89 ( 89 Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Journal Article · Sun Apr 01 00:00:00 EDT 2018 · Journal of Chromatography · OSTI ID:1427914

Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Journal Article · Fri Apr 13 00:00:00 EDT 2018 · Journal of Chromatography A · OSTI ID:1593331

Hydroxamate column-based purification of zirconium-89 (89Zr) using an automated fluidic platform

Journal Article · Wed Jan 31 23:00:00 EST 2018 · Applied Radiation and Isotopes · OSTI ID:1558198

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ImmunoPET
Zirconium-89
anion exchange
automation
fluoride complexation
medical isotope

Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform

Citation Formats

References (49)

Cited By (2)

Similar Records

Related Subjects

Optimized anion exchange column isolation of zirconium-89 (⁸⁹Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform