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An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery

Journal Article · · International Journal for Numerical Methods in Biomedical Engineering
DOI:https://doi.org/10.1002/cnm.2952· OSTI ID:1484705
 [1];  [2];  [3];  [4]
  1. Idaho National Lab. (INL), Idaho Falls, ID (United States). Modeling and Simulation
  2. Univ. of Colorado, Denver, CO (United States). School of Medicine
  3. Univ. of Texas, San Antonio, TX (United States). Dept. of Mechanical Engineering
  4. Univ. of Colorado, Boulder, CO (United States). Dept. of Computer Science
+ Show Author Affiliations
Simulation of blood flows in the pulmonary artery provides some insight into certain diseases by examining the relationship between some continuum metrics, eg, the wall shear stress acting on the vascular endothelium, which responds to flow-induced mechanical forces by releasing vasodilators/constrictors. V. Kheyfets, in his previous work, studies numerically a patient-specific pulmonary circulation to show that decreasing wall shear stress is correlated with increasing pulmonary vascular impedance. We develop a scalable parallel algorithm based on domain decomposition methods to investigate an unsteady model with patient-specific pulsatile waveforms as the inlet boundary condition. The unsteady model offers tremendously more information about the dynamic behavior of the flow field, but computationally speaking, the simulation is a lot more expensive since a problem which is similar to the steady-state problem has to be solved many times, and therefore, the traditional sequential approach is not suitable anymore. We show computationally that simulations using the proposed parallel approach with up to 10 000 processor cores can be obtained with much reduced compute time. Finally, this makes the technology potentially usable for the routine study of the dynamic behavior of blood flows in the pulmonary artery, in particular, the changes of the blood flows and the wall shear stress in the spatial and temporal dimensions.
Research Organization:
Idaho National Laboratory (INL), Idaho Falls, ID (United States)
Sponsoring Organization:
National Science Foundation (NSF) (United States); USDOE
Grant/Contract Number:
AC07-05ID14517
OSTI ID:
1484705
Alternate ID(s):
OSTI ID: 1419356
Report Number(s):
INL/JOU-17-42412-Rev001
Journal Information:
International Journal for Numerical Methods in Biomedical Engineering, Journal Name: International Journal for Numerical Methods in Biomedical Engineering Journal Issue: 4 Vol. 34; ISSN 2040-7939
Publisher:
WileyCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (2)

Simulation of unsteady blood flows in a patient‐specific compliant pulmonary artery with a highly parallel monolithically coupled fluid‐structure interaction algorithm
  • Kong, Fande; Kheyfets, Vitaly; Finol, Ender
  • International Journal for Numerical Methods in Biomedical Engineering, Vol. 35, Issue 7 https://doi.org/10.1002/cnm.3208
journal May 2019
Numerical aerodynamic simulation of transient flows around car based on parallel Newton–Krylov–Schwarz algorithm journal July 2019

Similar Records

Simulation of unsteady blood flows in a patient-specific compliant pulmonary artery with a highly parallel monolithically coupled fluid-structure interaction algorithm
Journal Article · Mon Apr 15 20:00:00 EDT 2019 · International Journal for Numerical Methods in Biomedical Engineering · OSTI ID:1631720

Related Subjects

60 APPLIED LIFE SCIENCES
domain decomposition
finite element
parallel processing
patient-specific pulmonary artery
unsteady blood flows