Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2 S ,5 R )-5-((7 H -Pyrrolo[2,3- d ]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
Journal Article
·
· Journal of Medicinal Chemistry
more »
- Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&,D, 1 Burtt Road, Andover, Massachusetts 01810, United States
Abstract not provided
- Research Organization:
- Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
- Sponsoring Organization:
- INDUSTRY
- OSTI ID:
- 1419053
- Journal Information:
- Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 5 Vol. 60; ISSN 0022-2623
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Discovery of 1-{(3 R ,4 R )-3-[({5-Chloro-2-[(1-methyl-1 H -pyrazol-4-yl)amino]-7 H -pyrrolo[2,3- d ]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5- d ]pyrrolo[2,3- b ]pyridine Inhibitors
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Journal Article
·
Wed Mar 09 23:00:00 EST 2016
· Journal of Medicinal Chemistry
·
OSTI ID:1405017
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5- d ]pyrrolo[2,3- b ]pyridine Inhibitors
Journal Article
·
Tue Jul 14 00:00:00 EDT 2015
· ACS Medicinal Chemistry Letters
·
OSTI ID:1397312
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Journal Article
·
Thu Oct 02 00:00:00 EDT 2014
· Journal of Medicinal Chemistry
·
OSTI ID:1093478