Three-Dimensional Microphase Separation and Synergistic Permeability in Stacked Lipid–Polymer Hybrid Membranes

Kang, Minjee; Lee, Byeongdu; Leal, Cecilia

doi:10.1021/acs.chemmater.7b02845

Title: Three-Dimensional Microphase Separation and Synergistic Permeability in Stacked Lipid–Polymer Hybrid Membranes

Journal Article · Fri Oct 20 00:00:00 EDT 2017 · Chemistry of Materials

DOI:https://doi.org/10.1021/acs.chemmater.7b02845· OSTI ID:1417194

^[1];

^[2];

^[1]

Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)
Argonne National Lab. (ANL), Argonne, IL (United States)

Here, we present new structures of soft-material thin films that augment the functionality of substrate-mediated delivery systems. A hybrid material composed of phospholipids and block copolymers adopts a multilayered membrane structure supported on a solid surface. The hybrid films comprise intentional intramembrane heterogeneities that register across multilayers. These stacked domains convey unprecedented enhancement and control of permeability of solutes across micrometer-thick films. Using grazing incidence X-ray scattering, phase contrast atomic force microscopy, and confocal microscopy, we observed that in each lamella, lipid and polymers partition unevenly within the membrane plane segregating into lipid- or polymer-rich domains. Interestingly, we found evidence that like-domains align in registry across multilayers, thereby making phase separation three-dimensional. Phase boundaries exist over extended length scales to compensate the height mismatch between lipid and polymer molecules. We show that microphase separation in hybrid films can be exploited to augment the capability of drug-eluting substrates. Lipid–polymer hybrid films loaded with paclitaxel show synergistic permeability of drug compared to single-component counterparts. We present a thorough structural study of stacked lipid–polymer hybrid membranes and propose that the presence of registered domains and domain boundaries impart enhanced drug release functionality. This work offers new perspectives in designing thin films for controlled delivery applications

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Institutes of Health (NIH); National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1417194

Journal Information:: Chemistry of Materials, Vol. 29, Issue 21; ISSN 0897-4756

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 17 works

Citation information provided by
Web of Science

References (104)

The Fluid Mosaic Model of the Structure of Cell Membranes Singer, S. J.; Nicolson, G. L. Science, Vol. 175, Issue 4023 https://doi.org/10.1126/science.175.4023.720	journal	February 1972
Thermal behavior of synthetic sphingomyelin-cholesterol dispersions Estep, T. N.; Mountcastle, D. B.; Barenholz, Y. Biochemistry, Vol. 18, Issue 10 https://doi.org/10.1021/bi00577a042	journal	May 1979
Luteolysis-induced changes in phase composition and fluidity of bovine luteal cell membranes. Goodsaid-Zalduondo, F.; Rintoul, D. A.; Carlson, J. C. Proceedings of the National Academy of Sciences, Vol. 79, Issue 14 https://doi.org/10.1073/pnas.79.14.4332	journal	July 1982
Lipid sorting in epithelial cells Simons, Kai; Van Meer, Gerrit Biochemistry, Vol. 27, Issue 17 https://doi.org/10.1021/bi00417a001	journal	August 1988
Functional rafts in cell membranes Simons, Kai; Ikonen, Elina Nature, Vol. 387, Issue 6633 https://doi.org/10.1038/42408	journal	June 1997
The challenge of lipid rafts Pike, Linda J. Journal of Lipid Research, Vol. 50 https://doi.org/10.1194/jlr.R800040-JLR200	journal	April 2009
Differential Targeting of Shaker-like Potassium Channels to Lipid Rafts Martens, Jeffrey R.; Navarro-Polanco, Ricardo; Coppock, Elizabeth A. Journal of Biological Chemistry, Vol. 275, Issue 11 https://doi.org/10.1074/jbc.275.11.7443	journal	March 2000
Localization of Cardiac Sodium Channels in Caveolin-Rich Membrane Domains: Regulation of Sodium Current Amplitude Yarbrough, Tracy L.; Lu, Tong; Lee, Hon-Chi Circulation Research, Vol. 90, Issue 4 https://doi.org/10.1161/hh0402.105177	journal	March 2002
Caveolae from canine airway smooth muscle contain the necessary components for a role in Ca ²⁺ handling Darby, Peter J.; Kwan, C. Y.; Daniel, Edwin E. American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 279, Issue 6 https://doi.org/10.1152/ajplung.2000.279.6.L1226	journal	December 2000
Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution Owen, Dylan M.; Williamson, David J.; Magenau, Astrid Nature Communications, Vol. 3, Issue 1 https://doi.org/10.1038/ncomms2273	journal	January 2012
Virus Entry, Assembly, Budding, and Membrane Rafts Chazal, Nathalie; Gerlier, Denis Microbiology and Molecular Biology Reviews, Vol. 67, Issue 2 https://doi.org/10.1128/MMBR.67.2.226-237.2003	journal	June 2003
Viral entry, lipid rafts and caveosomes Pietiäinen, Vilja M.; Marjomäki, Varpu; Heino, Jyrki Annals of Medicine, Vol. 37, Issue 6 https://doi.org/10.1080/07853890510011976	journal	January 2005
Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion Yang, Sung-Tae; Kiessling, Volker; Tamm, Lukas K. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms11401	journal	April 2016
Domains and Rafts in Lipid Membranes Binder, Wolfgang H.; Barragan, Veronique; Menger, Fredric M. Angewandte Chemie International Edition, Vol. 42, Issue 47 https://doi.org/10.1002/anie.200300586	journal	December 2003
Controlling the Localization of Polymer-Functionalized Nanoparticles in Mixed Lipid/Polymer Membranes Olubummo, Adekunle; Schulz, Matthias; Lechner, Bob-Dan ACS Nano, Vol. 6, Issue 10 https://doi.org/10.1021/nn3023602	journal	September 2012
Hybrid Polymer–Lipid Films as Platforms for Directed Membrane Protein Insertion Kowal, Justyna; Wu, Dalin; Mikhalevich, Viktoria Langmuir, Vol. 31, Issue 17 https://doi.org/10.1021/acs.langmuir.5b00388	journal	April 2015
Multilayered Lipid Membrane Stacks for Biocatalysis Using Membrane Enzymes Heath, George R.; Li, Mengqiu; Rong, Honling Advanced Functional Materials, Vol. 27, Issue 17 https://doi.org/10.1002/adfm.201606265	journal	March 2017
Soft Nanostructured Films for Actuated Surface-Based siRNA Delivery Kang, Minjee; Leal, Cecilia Advanced Functional Materials, Vol. 26, Issue 31 https://doi.org/10.1002/adfm.201600681	journal	July 2016
Self-organization of nucleic acids in lipid constructs Kang, Minjee; Kim, Hojun; Leal, Cecilia Current Opinion in Colloid & Interface Science, Vol. 26 https://doi.org/10.1016/j.cocis.2016.09.006	journal	December 2016
Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants Lee, Chi Hwan; Kim, Hojun; Harburg, Daniel V. NPG Asia Materials, Vol. 7, Issue 11 https://doi.org/10.1038/am.2015.114	journal	November 2015
Soft nanostructured films for directing the assembly of functional materials Steer, D.; Kang, M.; Leal, C. Nanotechnology, Vol. 28, Issue 14 https://doi.org/10.1088/1361-6528/aa5d77	journal	March 2017
Concurrent self-assembly of amphiphiles into nanoarchitectures with increasing complexity Liu, Yijing; Liu, Ben; Nie, Zhihong Nano Today, Vol. 10, Issue 3 https://doi.org/10.1016/j.nantod.2015.04.001	journal	June 2015
Mixed Hybrid Lipid/Polymer Vesicles as a Novel Membrane Platform Schulz, Matthias; Binder, Wolfgang H. Macromolecular Rapid Communications, Vol. 36, Issue 23 https://doi.org/10.1002/marc.201500344	journal	October 2015
Shape Control of Soft Nanoparticles and Their Assemblies Chen, Chao; Wylie, Ross A. L.; Klinger, Daniel Chemistry of Materials, Vol. 29, Issue 5 https://doi.org/10.1021/acs.chemmater.6b04700	journal	February 2017
Giant Phospholipid/Block Copolymer Hybrid Vesicles: Mixing Behavior and Domain Formation Nam, Jin; Beales, Paul A.; Vanderlick, T. Kyle Langmuir, Vol. 27, Issue 1 https://doi.org/10.1021/la103428g	journal	January 2011
Hybrid lipid/polymer giant unilamellar vesicles: effects of incorporated biocompatible PIB–PEO block copolymers on vesicle properties Schulz, Matthias; Glatte, Daniela; Meister, Annette Soft Matter, Vol. 7, Issue 18 https://doi.org/10.1039/c1sm05725a	journal	January 2011
Formation and dissolution of phospholipid domains with varying textures in hybrid lipo-polymersomes Nam, Jin; Vanderlick, T. Kyle; Beales, Paul A. Soft Matter, Vol. 8, Issue 30 https://doi.org/10.1039/c2sm25646k	journal	January 2012
Lateral surface engineering of hybrid lipid–BCP vesicles and selective nanoparticle embedding Schulz, Matthias; Olubummo, Adekunle; Bacia, Kirsten Soft Matter, Vol. 10, Issue 6 https://doi.org/10.1039/C3SM52040D	journal	January 2014
Hybrid copolymer–phospholipid vesicles: phase separation resembling mixed phospholipid lamellae, but with mechanical stability and control Chen, Dong; Santore, Maria M. Soft Matter, Vol. 11, Issue 13 https://doi.org/10.1039/C4SM02502D	journal	January 2015
Modulation of phase separation at the micron scale and nanoscale in giant polymer/lipid hybrid unilamellar vesicles (GHUVs) Dao, Thi Phuong Tuyen; Fernandes, Fabio; Ibarboure, Emmanuel Soft Matter, Vol. 13, Issue 3 https://doi.org/10.1039/C6SM01625A	journal	January 2017
Mixing Block Copolymers with Phospholipids at the Nanoscale: From Hybrid Polymer/Lipid Wormlike Micelles to Vesicles Presenting Lipid Nanodomains Dao, T. P. Tuyen; Brûlet, A.; Fernandes, F. Langmuir, Vol. 33, Issue 7 https://doi.org/10.1021/acs.langmuir.6b04478	journal	February 2017
Mixing, Diffusion, and Percolation in Binary Supported Membranes Containing Mixtures of Lipids and Amphiphilic Block Copolymers Gettel, Douglas L.; Sanborn, Jeremy; Patel, Mira A. Journal of the American Chemical Society, Vol. 136, Issue 29 https://doi.org/10.1021/ja5037308	journal	July 2014
Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch Itel, Fabian; Najer, Adrian; Palivan, Cornelia G. Nano Letters, Vol. 15, Issue 6 https://doi.org/10.1021/acs.nanolett.5b00699	journal	May 2015
Controlling Polymersome Surface Topology at the Nanoscale by Membrane Confined Polymer/Polymer Phase Separation LoPresti, Caterina; Massignani, Marzia; Fernyhough, Christine ACS Nano, Vol. 5, Issue 3 https://doi.org/10.1021/nn102455z	journal	February 2011
Hybrid polymer/lipid vesicles: state of the art and future perspectives Le Meins, J-F.; Schatz, C.; Lecommandoux, S. Materials Today, Vol. 16, Issue 10 https://doi.org/10.1016/j.mattod.2013.09.002	journal	October 2013
Beyond the lipid-bilayer: interaction of polymers and nanoparticles with membranes Schulz, Matthias; Olubummo, Adekunle; Binder, Wolfgang H. Soft Matter, Vol. 8, Issue 18 https://doi.org/10.1039/c2sm06999g	journal	January 2012
Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces Hinman, Samuel S.; Ruiz, Charles J.; Cao, Yu ACS Applied Materials & Interfaces, Vol. 9, Issue 1 https://doi.org/10.1021/acsami.6b11556	journal	December 2016
Stacked, Folded, and Bent Lipid Membranes Sasaki, Darryl Y.; Stevens, Mark J. MRS Bulletin, Vol. 31, Issue 7 https://doi.org/10.1557/mrs2006.136	journal	July 2006
Membrane curvature and mechanisms of dynamic cell membrane remodelling McMahon, Harvey T.; Gallop, Jennifer L. Nature, Vol. 438, Issue 7068 https://doi.org/10.1038/nature04396	journal	November 2005
Lateral heterogeneity of plant thylakoid protein complexes: early reminiscences Anderson, Jan M. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 367, Issue 1608 https://doi.org/10.1098/rstb.2012.0060	journal	December 2012
Structure and dynamics of thylakoids in land plants Pribil, Mathias; Labs, Mathias; Leister, Dario Journal of Experimental Botany, Vol. 65, Issue 8 https://doi.org/10.1093/jxb/eru090	journal	March 2014
Differential Mobility of Pigment-Protein Complexes in Granal and Agranal Thylakoid Membranes of C ₃ and C ₄ Plants Kirchhoff, Helmut; Sharpe, Richard M.; Herbstova, Miroslava Plant Physiology, Vol. 161, Issue 1 https://doi.org/10.1104/pp.112.207548	journal	November 2012
Drug Releasing Polymer Thin Films: New Era of Surface-Mediated Drug Delivery Zelikin, Alexander N. ACS Nano, Vol. 4, Issue 5 https://doi.org/10.1021/nn100634r	journal	March 2010
Macroscale delivery systems for molecular and cellular payloads Kearney, Cathal J.; Mooney, David J. Nature Materials, Vol. 12, Issue 11 https://doi.org/10.1038/nmat3758	journal	October 2013
Template Synthesis of Nanostructured Materials via Layer-by-Layer Assembly ^† Wang, Yajun; Angelatos, Alexandra S.; Caruso, Frank Chemistry of Materials, Vol. 20, Issue 3 https://doi.org/10.1021/cm7024813	journal	February 2008
In vitro study of release mechanisms of paclitaxel and rapamycin from drug-incorporated biodegradable stent matrices Alexis, Frank; Venkatraman, Subbu S.; Rath, Santosh Kumar Journal of Controlled Release, Vol. 98, Issue 1 https://doi.org/10.1016/j.jconrel.2004.04.011	journal	July 2004
Layer-by-layer assembly of cationic lipid and plasmid DNA onto gold surface for stent-assisted gene transfer Yamauchi, Fumio; Koyamatsu, Yuichi; Kato, Koichi Biomaterials, Vol. 27, Issue 18 https://doi.org/10.1016/j.biomaterials.2006.02.004	journal	June 2006
Polyelectrolyte Multilayer Assemblies on Materials Surfaces: From Cell Adhesion to Tissue Engineering Gribova, Varvara; Auzely-Velty, Rachel; Picart, Catherine Chemistry of Materials, Vol. 24, Issue 5 https://doi.org/10.1021/cm2032459	journal	December 2011
Chemically Detachable Polyelectrolyte Multilayer Platform for Cell Sheet Engineering Chassepot, Armelle; Gao, Longcheng; Nguyen, Isabelle Chemistry of Materials, Vol. 24, Issue 5 https://doi.org/10.1021/cm2024982	journal	December 2011
Patterned Poly(dopamine) Films for Enhanced Cell Adhesion Chen, Xi; Cortez-Jugo, Christina; Choi, Gwan H. Bioconjugate Chemistry, Vol. 28, Issue 1 https://doi.org/10.1021/acs.bioconjchem.6b00544	journal	October 2016
Irena : tool suite for modeling and analysis of small-angle scattering Ilavsky, Jan; Jemian, Peter R. Journal of Applied Crystallography, Vol. 42, Issue 2 https://doi.org/10.1107/S0021889809002222	journal	February 2009
Synthesis, Characterization, and Paclitaxel Release from a Biodegradable, Elastomeric, Poly(ester urethane)urea Bearing Phosphorylcholine Groups for Reduced Thrombogenicity Hong, Yi; Ye, Sang-Ho; Pelinescu, Anca L. Biomacromolecules, Vol. 13, Issue 11 https://doi.org/10.1021/bm301158j	journal	September 2012
Role of Cholesterol in the Formation and Nature of Lipid Rafts in Planar and Spherical Model Membranes Crane, Jonathan M.; Tamm, Lukas K. Biophysical Journal, Vol. 86, Issue 5 https://doi.org/10.1016/S0006-3495(04)74347-7	journal	May 2004
Domain Formation and Stability in Complex Lipid Bilayers as Reported by Cholestatrienol Björkqvist, Y. Jenny E.; Nyholm, Thomas K. M.; Slotte, J. Peter Biophysical Journal, Vol. 88, Issue 6 https://doi.org/10.1529/biophysj.104.054718	journal	June 2005
The Effect of Membrane Lipid Composition on the Formation of Lipid Ultrananodomains Pathak, Priyadarshini; London, Erwin Biophysical Journal, Vol. 109, Issue 8 https://doi.org/10.1016/j.bpj.2015.08.029	journal	October 2015
A Correlation between Lipid Domain Shape and Binary Phospholipid Mixture Composition in Free Standing Bilayers: A Two-Photon Fluorescence Microscopy Study Bagatolli, Luis A.; Gratton, Enrico Biophysical Journal, Vol. 79, Issue 1 https://doi.org/10.1016/S0006-3495(00)76305-3	journal	July 2000
Steric Interaction of Fluid Membranes in Multilayer Systems Helfrich, W. Zeitschrift für Naturforschung A, Vol. 33, Issue 3 https://doi.org/10.1515/zna-1978-0308	journal	January 1978
Thermal-mechanical fluctuations enhance repulsion between bimolecular layers. Evans, E. A.; Parsegian, V. A. Proceedings of the National Academy of Sciences, Vol. 83, Issue 19 https://doi.org/10.1073/pnas.83.19.7132	journal	October 1986
New insights into water–phospholipid model membrane interactions Milhaud, Jeannine Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1663, Issue 1-2 https://doi.org/10.1016/j.bbamem.2004.02.003	journal	May 2004
Line Tension and Interaction Energies of Membrane Rafts Calculated from Lipid Splay and Tilt Kuzmin, Peter I.; Akimov, Sergey A.; Chizmadzhev, Yuri A. Biophysical Journal, Vol. 88, Issue 2 https://doi.org/10.1529/biophysj.104.048223	journal	February 2005
Dilatometric studies of the subtransition in dipalmitoylphosphatidylcholine Nagle, John F.; Wilkinson, D. Allan Biochemistry, Vol. 21, Issue 16 https://doi.org/10.1021/bi00259a015	journal	August 1982
Lipid bilayers: thermodynamics, structure, fluctuations, and interactions Tristram-Nagle, Stephanie; Nagle, John F. Chemistry and Physics of Lipids, Vol. 127, Issue 1 https://doi.org/10.1016/j.chemphyslip.2003.09.002	journal	January 2004
Topographic and phase-contrast imaging in atomic force microscopy Pang, Geoffrey K. H.; Baba-Kishi, K. Z.; Patel, A. Ultramicroscopy, Vol. 81, Issue 2 https://doi.org/10.1016/S0304-3991(99)00164-3	journal	March 2000
Characterization of Heterogeneous Regions in Polymer Systems Using Tapping Mode and Force Mode Atomic Force Microscopy Raghavan, D.; VanLandingham, M.; Gu, X. Langmuir, Vol. 16, Issue 24 https://doi.org/10.1021/la991694w	journal	November 2000
Molecular Simulation Study of Structural and Dynamic Properties of Mixed DPPC/DPPE Bilayers Leekumjorn, Sukit; Sum, Amadeu K. Biophysical Journal, Vol. 90, Issue 11 https://doi.org/10.1529/biophysj.105.076596	journal	June 2006
A mechanistic study on amphiphilic block co-polymer poly(butadiene-b-(ethylene oxide)) vesicles reveals the water permeation mechanism through a polymeric bilayer He, Fang; Tong, Yen Wah RSC Adv., Vol. 4, Issue 29 https://doi.org/10.1039/C3RA48063A	journal	January 2014
Paclitaxel: An Update of its Use in the Treatment of Metastatic Breast Cancer and Ovarian and Other Gynaecological Cancers Wiseman, Lynda R.; Spencer, Caroline M. Drugs & Aging, Vol. 12, Issue 4 https://doi.org/10.2165/00002512-199812040-00005	journal	January 1998
Taxol: a new and effective anti-cancer drug Slichenmyer, William J.; Von Hoff, Daniel D. Anti-Cancer Drugs, Vol. 2, Issue 6 https://doi.org/10.1097/00001813-199112000-00002	journal	January 1991
Peripheral Neuropathy Induced by Paclitaxel: Recent Insights and Future Perspectives Scripture, Charity; Figg, William; Sparreboom, Alex Current Neuropharmacology, Vol. 4, Issue 2 https://doi.org/10.2174/157015906776359568	journal	April 2006
Biocompatibility aspects of new stent technology Bertrand, Olivier F.; Sipehia, Rajender; Mongrain, Rosaire Journal of the American College of Cardiology, Vol. 32, Issue 3 https://doi.org/10.1016/S0735-1097(98)00289-7	journal	September 1998
Drug-eluting stent safety: findings from preclinical studies Nakazawa, Gaku; Finn, Aloke V.; Ladich, Elena Expert Review of Cardiovascular Therapy, Vol. 6, Issue 10 https://doi.org/10.1586/14779072.6.10.1379	journal	November 2008
Heterogeneous and homogeneous nucleation of Taxol™ crystals in aqueous solutions and gels: Effect of tubulin proteins Castro, Javier S.; Deymier, Pierre A.; Trzaskowski, Bartosz Colloids and Surfaces B: Biointerfaces, Vol. 76, Issue 1 https://doi.org/10.1016/j.colsurfb.2009.10.033	journal	March 2010
Liposomal paclitaxel formulations Koudelka, Štěpán; Turánek, Jaroslav Journal of Controlled Release, Vol. 163, Issue 3 https://doi.org/10.1016/j.jconrel.2012.09.006	journal	November 2012
Paclitaxel Partitioning into Lipid Bilayers Wenk, Markus R.; Fahr, Alfred; Reszka, Regina Journal of Pharmaceutical Sciences, Vol. 85, Issue 2 https://doi.org/10.1021/js950120i	journal	February 1996
Solvent- and Concentration-Dependent Molecular Interactions of Taxol (Paclitaxel †) Balasubramanian, Sathyamangalam V.; Alderfer, James L.; Straubinger, Robert M. Journal of Pharmaceutical Sciences, Vol. 83, Issue 10 https://doi.org/10.1002/jps.2600831021	journal	October 1994
Crystal and molecular structure of paclitaxel (taxol). Mastropaolo, D.; Camerman, A.; Luo, Y. Proceedings of the National Academy of Sciences, Vol. 92, Issue 15 https://doi.org/10.1073/pnas.92.15.6920	journal	July 1995
Molecular Simulation of the Concentration-Dependent Interaction of Hydrophobic Drugs with Model Cellular Membranes Kang, Myungshim; Loverde, Sharon M. The Journal of Physical Chemistry B, Vol. 118, Issue 41 https://doi.org/10.1021/jp5047613	journal	October 2014
A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect Kan, Pei; Tsao, Chih-Wan; Wang, Ae-June Journal of Drug Delivery, Vol. 2011 https://doi.org/10.1155/2011/629234	journal	October 2011
Simulating X-ray diffraction of textured films Breiby, Dag W.; Bunk, Oliver; Andreasen, Jens W. Journal of Applied Crystallography, Vol. 41, Issue 2 https://doi.org/10.1107/S0021889808001064	journal	March 2008
Quantification of Thin Film Crystallographic Orientation Using X-ray Diffraction with an Area Detector Baker, Jessy L.; Jimison, Leslie H.; Mannsfeld, Stefan Langmuir, Vol. 26, Issue 11 https://doi.org/10.1021/la904840q	journal	June 2010
Acyl-Chain Correlation in Membrane Fusion Intermediates: X-Ray Diffraction from the Rhombohedral Lipid Phase Weinhausen, Britta; Aeffner, Sebastian; Reusch, Tobias Biophysical Journal, Vol. 102, Issue 9 https://doi.org/10.1016/j.bpj.2012.03.069	journal	May 2012
Order and disorder in fully hydrated unoriented bilayers of gel-phase dipalmitoylphosphatidylcholine Sun, W. -J.; Suter, R. M.; Knewtson, M. A. Physical Review E, Vol. 49, Issue 5 https://doi.org/10.1103/PhysRevE.49.4665	journal	May 1994
Interaction of Aspirin (Acetylsalicylic Acid) with Lipid Membranes Barrett, Matthew A.; Zheng, Songbo; Roshankar, Golnaz PLoS ONE, Vol. 7, Issue 4 https://doi.org/10.1371/journal.pone.0034357	journal	April 2012
First order melting transitions of highly ordered dipalmitoyl phosphatidylcholine gel phase membranes in molecular dynamics simulations with atomistic detail Schubert, Thomas; Schneck, Emanuel; Tanaka, Motomu The Journal of Chemical Physics, Vol. 135, Issue 5 https://doi.org/10.1063/1.3615937	journal	August 2011
Evidence for a Two-Dimensional Molecular Lattice in Subgel Phase DPPC Bilayers Katsaras, J.; Raghunathan, V. A.; Dufourc, E. J. Biochemistry, Vol. 34, Issue 14 https://doi.org/10.1021/bi00014a023	journal	April 1995
The Observation of Highly Ordered Domains in Membranes with Cholesterol Armstrong, Clare L.; Marquardt, Drew; Dies, Hannah PLoS ONE, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pone.0066162	journal	June 2013
Cholesterol expels ibuprofen from the hydrophobic membrane core and stabilizes lamellar phases in lipid membranes containing ibuprofen Alsop, Richard J.; Armstrong, Clare L.; Maqbool, Amna Soft Matter, Vol. 11, Issue 24 https://doi.org/10.1039/C5SM00597C	journal	January 2015
Effects of cholesterol and unsaturated DOPC lipid on chain packing of saturated gel-phase DPPC bilayers Mills, T.; Huang, J.; Feigenson, G. General Physiology and Biophysics, Vol. 28, Issue 2 https://doi.org/10.4149/gpb_2009_02_126	journal	January 2009
The Diversity of the Liquid Ordered (Lo) Phase of Phosphatidylcholine/Cholesterol Membranes: A Variable Temperature Multinuclear Solid-State NMR and X-Ray Diffraction Study Clarke, James A.; Heron, Andrew J.; Seddon, John M. Biophysical Journal, Vol. 90, Issue 7 https://doi.org/10.1529/biophysj.104.056499	journal	April 2006
Distinct solubility and cytotoxicity regimes of paclitaxel-loaded cationic liposomes at low and high drug content revealed by kinetic phase behavior and cancer cell viability studies Steffes, Victoria M.; Murali, Meena M.; Park, Yoonsang Biomaterials, Vol. 145 https://doi.org/10.1016/j.biomaterials.2017.08.026	journal	November 2017
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices Higuchi, T. Journal of Pharmaceutical Sciences, Vol. 52, Issue 12 https://doi.org/10.1002/jps.2600521210	journal	December 1963
On the importance and mechanisms of burst release in matrix-controlled drug delivery systems Huang, Xiao; Brazel, Christopher S. Journal of Controlled Release, Vol. 73, Issue 2-3 https://doi.org/10.1016/S0168-3659(01)00248-6	journal	June 2001
Role of lipid polymorphism in acoustically sensitive liposomes Kang, Minjee; Huang, Grace; Leal, Cecilia Soft Matter, Vol. 10, Issue 44 https://doi.org/10.1039/C4SM01431F	journal	January 2014
Mechanisms of solute release from porous hydrophilic polymers Korsmeyer, Richard W.; Gurny, Robert; Doelker, Eric International Journal of Pharmaceutics, Vol. 15, Issue 1 https://doi.org/10.1016/0378-5173(83)90064-9	journal	May 1983
A model of dissolution-controlled solute release from porous drug delivery polymeric systems Peppas, Nikolaos A. Journal of Biomedical Materials Research, Vol. 17, Issue 6 https://doi.org/10.1002/jbm.820170615	journal	November 1983
Dependence of Reaction Velocity upon surface and Agitation Hixson, A. W.; Crowell, J. H. Industrial & Engineering Chemistry, Vol. 23, Issue 8 https://doi.org/10.1021/ie50260a018	journal	August 1931
Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis Zhang, Hua; Hu, Hongxiang; Zhang, Haoran Nanoscale, Vol. 7, Issue 24 https://doi.org/10.1039/C4NR07450E	journal	January 2015
A self-assembling nanomedicine of conjugated linoleic acid-paclitaxel conjugate (CLA-PTX) with higher drug loading and carrier-free characteristic Zhong, Ting; Yao, Xin; Zhang, Shuang Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep36614	journal	November 2016
Molecular studies of the gel to liquid-crystalline phase transition for fully hydrated DPPC and DPPE bilayers Leekumjorn, Sukit; Sum, Amadeu K. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1768, Issue 2 https://doi.org/10.1016/j.bbamem.2006.11.003	journal	February 2007
Passive ion permeability of lipid membranes modelled via lipid-domain interfacial area Cruzeiro-Hansson, Leonor; Mouritsen, Ole G. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 944, Issue 1 https://doi.org/10.1016/0005-2736(88)90316-1	journal	September 1988
Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations Zhernenkov, Mikhail; Bolmatov, Dima; Soloviov, Dmitry Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms11575	journal	May 2016
Phase behavior and permeability properties of phospholipid bilayers containing a short-chain phospholipid permeability enhancer Risbo, Jens; Jørgensen, Kent; Sperotto, Maria M. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1329, Issue 1 https://doi.org/10.1016/S0005-2736(97)00091-6	journal	October 1997
Interactions of Amphiphilic Triblock Copolymers with Lipid Membranes: Modes of Interaction and Effect on Permeability Examined by Generic Monte Carlo Simulations Rabbel, Hauke; Werner, Marco; Sommer, Jens-Uwe Macromolecules, Vol. 48, Issue 13 https://doi.org/10.1021/acs.macromol.5b00720	journal	June 2015
Anhydrous Proton Transport in Polymerized Ionic Liquid Block Copolymers: Roles of Block Length, Ionic Content, and Confinement Evans, Christopher M.; Sanoja, Gabriel E.; Popere, Bhooshan C. Macromolecules, Vol. 49, Issue 1 https://doi.org/10.1021/acs.macromol.5b02202	journal	December 2015

Cited By (3)

Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology Kang, Minjee; Tuteja, Mohit; Centrone, Andrea Advanced Functional Materials, Vol. 28, Issue 9 https://doi.org/10.1002/adfm.201704356	journal	January 2018
Lipid-based liquid crystalline films and solutions for the delivery of cargo to cells Porras-Gomez, Marilyn; Leal, Cecilia Liquid Crystals Reviews, Vol. 7, Issue 2 https://doi.org/10.1080/21680396.2019.1666752	journal	July 2019
Large and Giant Unilamellar Vesicle(s) Obtained by Self-Assembly of Poly(dimethylsiloxane)-b-poly(ethylene oxide) Diblock Copolymers, Membrane Properties and Preliminary Investigation of Their Ability to Form Hybrid Polymer/Lipid Vesicles Fauquignon, Martin; Ibarboure, Emmanuel; Carlotti, Stéphane Polymers, Vol. 11, Issue 12 https://doi.org/10.3390/polym11122013	journal	December 2019

Similar Records

Measuring the structure of thin soft matter films under confinement: A surface-force type apparatus for neutron reflection, based on a flexible membrane approach

Journal Article · Thu Nov 15 00:00:00 EST 2012 · Review of Scientific Instruments · OSTI ID:1417194

Vos, Wiebe M. de; Mears, Laura L. E.; Richardson, Robert M.; +3 more

Hybrid Unilamellar Vesicles of Phospholipids and Block Copolymers with Crystalline Domains

Journal Article · Fri May 29 00:00:00 EDT 2020 · Polymers · OSTI ID:1417194

Go, Yoo Kyung; Kambar, Nurila; Leal, Cecilia

Microphase separation in thin films of lamellar forming polydisperse di-block copolymers

Journal Article · Tue Feb 03 00:00:00 EST 2015 · RSC Advances · OSTI ID:1417194

Kumar, Rajeev; Lokitz, Bradley S.; Sides, Scott W.; +6 more

Related Subjects

36 MATERIALS SCIENCE
interlayer stacked domains
lipid domains
lipid-polymer hybrids
multilayer membranes
paclitaxel
permeability

Title: Three-Dimensional Microphase Separation and Synergistic Permeability in Stacked Lipid–Polymer Hybrid Membranes

Citation Formats

References (104)

Cited By (3)

Similar Records

Related Subjects