Novel thermo-sensitive amphiphilic gels: Poly-N-isopropylacrylamide-co-sodium acrylate-co-n-N-alkylacrylamide network synthesis and physicochemical characterization
- Oregon Graduate Institute of Science & Technology, Beaverton, OR (United States)
Hydrogels have been used by many investigators in controlled release technology because of their good biocompatibility and easy regulation of solute permeability. In this paper, novel thermosensitive amphiphilic gels, poly(N-isopropylacrylamide-co-sodium acrylate-co-n-N=alkylacrylamide) networks, were synthesized via micellar polymerization methods. These gels demonstrate some remarkable physicochemical properties in terms of temperature-dependent swelling behavior and long-term sustained release characteristics (over one thousand hours) for amphiphiles. The preliminary release characteristics of a model amphiphile, sodium dodecyl sulfate (SDS), from these gels are studied by varying the amount and types of incorporation of the hydrophobic co-monomer, n-N-alkylacrylamide, into the networks. The swelling ratio and thermosensitive critical point can be adjusted by varying the amount of incorporation of the hydrophilic co-monomer, sodium acrylate.
- OSTI ID:
- 141706
- Report Number(s):
- CONF-930304-; TRN: 93:003688-1388
- Resource Relation:
- Conference: 205. American Chemical Society national meeting, Denver, CO (United States), 28 Mar - 2 Apr 1993; Other Information: PBD: 1993; Related Information: Is Part Of 205th ACS national meeting; PB: 1951 p.
- Country of Publication:
- United States
- Language:
- English
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