Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition: Catalytic Mechanism of cGAS

Journal Article · · Protein Science
DOI:https://doi.org/10.1002/pro.3304· OSTI ID:1414459
 [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [2];  [3];  [1];  [1];  [2];  [1];  [1]
  1. Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton Connecticut 06340
  2. Hit Discovery and Lead Profiling, Pfizer Centers for Therapeutic Innovation (CTI), Pfizer, Eastern Point Road, Groton Connecticut 06340
  3. Worldwide Medicinal Chemistry, Pfizer, 610 Main St, Cambridge Massachusetts 02139
+ Show Author Affiliations
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
INDUSTRY
OSTI ID:
1414459
Journal Information:
Protein Science, Journal Name: Protein Science Journal Issue: 12 Vol. 26; ISSN 0961-8368
Publisher:
The Protein Society
Country of Publication:
United States
Language:
ENGLISH

Similar Records

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP
Journal Article · Thu Jul 03 00:00:00 EDT 2014 · Nat. Struct. Mol. Biol. · OSTI ID:1131361
Cyclic GMP-AMP Synthase is Activated by Double-Stranded DNA-induced Oligomerization
Journal Article · Thu Oct 02 00:00:00 EDT 2014 · Immunity 39, 1019 (2013) · OSTI ID:1185155
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
Journal Article · Sun Jul 05 20:00:00 EDT 2015 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1213725

Related Subjects