The Role of Extracellular Fluid in Biokinetic Modeling
- Santa Fe, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Melohill Technology, LLC, Rockville, MD (United States)
Here, the pharmacokinetic equations of Pierson et al. describing the behavior of bromide in rat provide a general approach to the modeling of extracellular fluid (ECF). The movement of material into ECF spaces is rapid and is completely characterized by tissue volumes and vascular flow rates to and from a tissue, the volumes of the tissue, and the ECF associated with the tissue. Early-time measurements are needed to characterize ECF. Measurements of DTPA disappearance from plasma by Wedeking et al. are discussed as an example of such measurements. In any biokinetic model, the fastest transfer rates are not determinable with the usual datasets, and if determined empirically, these rates will have very large and highly correlated uncertainties, so particular values of these rates, even though the model fits the available data, are not significant. A pharmacokinetic front-end provides values for these fast rates. An example of such a front-end for a 200–g rat is given.
- Research Organization:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1414152
- Report Number(s):
- LA-UR-17-23147; TRN: US1800674
- Journal Information:
- Health Physics, Vol. 113, Issue 6; ISSN 0017-9078
- Publisher:
- Health Physics SocietyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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