Naphthalenedisulfonic acid derivatives inhibit HIV-1-induced cytopathogenesis, syncytia formation and virus-cell binding by interaction with the viral envelope glycoprotein

Conference · Fri Dec 31 04:00:00 EST 1993

OSTI ID:141125

Mohan, P ^[1]; Schols, D; De Clercq, E ^[2]; Shigeta, S; Baba, M ^[3]

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1. Univ. of Illinois, Chicago, IL (United States)
2. Katholieke Universiteit Leuven (Belgium)
3. Fukushima Medical College (Japan)

Bis naphthalenedisulfonic acid analogs with biphenyl spacers have exhibited potent and selective inhibition of HIV-1 replication and giant cell formation. FACS analysis has revealed that these agents also inhibit viral binding to the target cell. Further mechanism of action studies by the FACA method demonstrate that the sulfonic acid analogs inhibit binding of anti-gp120 monoclonal antibody to the viral envelope of glycoprotein, gp120. Binding of OKT4A/Leu3a monoclonal antibody to the target cell CD4 receptor is not affected by these compounds. This investigation suggests that these naphthalenedisulfonic acid derivatives exert their anti-HIV-1 activity by inhibiting the gp120-CD4 interaction through binding of these agents to the viral gp120 antigen.

• OSTI ID: 141125
• Report Number(s): CONF-930304--
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
55 BIOLOGY AND MEDICINE
BASIC STUDIES
AIDS VIRUS
ANTI-INFECTIVE AGENTS
BIOCHEMISTRY
CELL MEMBRANES
GLYCOPROTEINS
HYDROAROMATICS
INHIBITION
MEDICINE
SULFONIC ACIDS
THERAPEUTIC USES