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Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

Journal Article · · PLoS ONE
Not Available
Research Organization:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Organization:
LLNL Laboratory Directed Research and Development (LDRD) Program; USDOE
Grant/Contract Number:
AC52-07NA27344
OSTI ID:
1410403
Alternate ID(s):
OSTI ID: 1458683
Report Number(s):
LLNL-JRNL--737141; 10.1371/journal.pone.0188264
Journal Information:
PLoS ONE, Journal Name: PLoS ONE Journal Issue: 11 Vol. 12; ISSN 1932-6203
Publisher:
Public Library of ScienceCopyright Statement
Country of Publication:
United States
Language:
English

References (54)

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Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways: Wnt INHIBITS OC DIFFERENTIATION BY CANONICAL/NONCANONICAL PATHWAYS journal August 2015
Biphasic effects of transforming growth factor β on bone morphogenetic protein-induced osteoblast differentiation journal May 2011
Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells journal January 2004
Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cells journal April 2012
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Ectopic Expression of SOX9 in Osteoblasts Alters Bone Mechanical Properties journal December 2011
Crucial roles of canonical Runx2-dependent pathway on Wnt1-induced osteoblastic differentiation of human periodontal ligament fibroblasts journal January 2015
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LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development journal November 2001
Mutations in WNT1 Cause Different Forms of Bone Fragility journal April 2013
Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells journal September 2011
Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells journal April 2005
High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes journal November 2011
Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner journal September 2012
E2F1 effects on osteoblast differentiation and mineralization are mediated through up-regulation of frizzled-1 journal October 2013
Transcriptional control of Sost in bone journal March 2017
Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation journal August 2006
An LDL-receptor-related protein mediates Wnt signalling in mice journal September 2000
Vitamin D endocrine system and osteoblasts journal February 2014
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High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5 journal May 2002
Regulation of osteoblastogenesis and bone mass by Wnt10b journal February 2005
Epidermal Growth Factor Receptor (EGFR) Signaling Promotes Proliferation and Survival in Osteoprogenitors by Increasing Early Growth Response 2 (EGR2) Expression journal May 2013
Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation journal January 2016
Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation journal April 2016
The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment journal June 2006
Wnt11 Promotes Osteoblast Maturation and Mineralization through R-spondin 2 journal February 2009
Cbfa1 -independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor journal April 2002
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FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis journal April 2002
Wnt Proteins Promote Bone Regeneration journal April 2010
Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast journal March 2015
CCN1/Cyr61 Is Regulated by the Canonical Wnt Signal and Plays an Important Role in Wnt3A-Induced Osteoblast Differentiation of Mesenchymal Stem Cells journal March 2006
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Building bone to reverse osteoporosis and repair fractures journal February 2008
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Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice journal January 2009
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6 journal September 2004
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation journal August 2007
BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop journal October 2003
Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition journal May 2013
SOST Inhibits Prostate Cancer Invasion journal November 2015
Platelet-derived growth factor promotes osteoblast proliferation by activating G-protein-coupled receptor kinase interactor-1 journal July 2014
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation journal January 2012

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