Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

Mastren, Tara; Radchenko, Valery; Engle, Jonathan W.; Weidner, John W.; Owens, Allison; Wyant, Lance E.; Copping, Roy; Brugh, Mark; Nortier, F. Meiring; Birnbaum, Eva R.; John, Kevin D.; Fassbender, Michael E.

doi:10.1016/j.aca.2017.10.020

Title: Chromatographic separation of the theranostic radionuclide ¹¹¹Ag from a proton irradiated thorium matrix

Journal Article · Mon Oct 30 00:00:00 EDT 2017 · Analytica Chimica Acta

DOI:https://doi.org/10.1016/j.aca.2017.10.020· OSTI ID:1409773

Mastren, Tara ^[1]; Radchenko, Valery ^[1]; Engle, Jonathan W. ^[1]; Weidner, John W. ^[1]; Owens, Allison ^[2]; Wyant, Lance E. ^[2]; Copping, Roy ^[2]; Brugh, Mark ^[1]; Nortier, F. Meiring ^[1]; Birnbaum, Eva R. ^[1]; John, Kevin D. ^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division

Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. Herein we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of 111Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.

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Research Organization:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP); LANL Laboratory Directed Research and Development (LDRD) Program

Grant/Contract Number:: AC52-06NA25396; AC05-00OR22725; LDRD 20160439ER

OSTI ID:: 1409773

Alternate ID(s):: OSTI ID: 1435228; OSTI ID: 1562756

Report Number(s):: LA-UR-17-23917

Journal Information:: Analytica Chimica Acta, Vol. 998; ISSN 0003-2670

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 13 works

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Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium Fitzsimmons, Jonathan; Griswold, Justin; Medvedev, Dmitri Molecules, Vol. 24, Issue 6 https://doi.org/10.3390/molecules24061095	journal	March 2019
Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf Huang, Yaoyao; Hu, Yang; Chen, Lvcun PLOS ONE, Vol. 13, Issue 3 https://doi.org/10.1371/journal.pone.0193659	journal	March 2018

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
111Ag
CL resin
theranostic
thorium target
proton irradiation
nuclear reaction cross sections

Title: Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

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