Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions

Mohapatra, Sarat; Samanta, Subarna; Kothari, Khushboo; Mistry, Pinal; Suryanarayanan, Raj

doi:10.1021/acs.cgd.7b00096

Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions

Journal Article · Fri May 12 00:00:00 EDT 2017 · Crystal Growth and Design

DOI:https://doi.org/10.1021/acs.cgd.7b00096· OSTI ID:1406631

Mohapatra, Sarat ^[1]; Samanta, Subarna ^[1]; Kothari, Khushboo ^[1]; Mistry, Pinal ^[1]; Suryanarayanan, Raj ^[1]

Univ. of Minnesota, Minneapolis, MN (United States)

The influence of the molecular weight of polyvinylpyrrolidone (PVP) on the molecular mobility and physical stability of indomethacin (IMC)–PVP solid dispersions was investigated over a wide temperature range in the supercooled state. As the polymer molecular weight increased, there was a decrease in molecular mobility as evident from the longer α-relaxation times. Inhibition of IMC crystallization also increased as a function of polymer molecular weight. The extent of H-bonding interaction between drug and polymer, quantified by ssNMR, was independent of polymer molecular weight. Over a polymer concentration range of 5–20% w/w, the temperature dependence of mobility and viscosity was reasonably similar for different grades of PVP. Here, it was concluded that the increase in effectiveness in crystallization inhibition as a function of polymer molecular weight is due to the increased viscosity, which slows down the mobility of these systems.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1406631

Journal Information:: Crystal Growth and Design, Journal Name: Crystal Growth and Design Journal Issue: 6 Vol. 17; ISSN 1528-7483

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions

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