Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes

Wu, Lindsay E.; Levina, Aviva; Harris, Hugh H.; Cai, Zhonghou; Lai, Barry; Vogt, Stefan; James, David E.; Lay, Peter A.

doi:10.1002/anie.201509065

Title: Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes

Journal Article · Tue Dec 22 00:00:00 EST 2015 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.201509065· OSTI ID:1401851

^[1]; Levina, Aviva ^[2];

^[3]; Cai, Zhonghou ^[4]; Lai, Barry ^[4];

^[4]; James, David E. ^[5];

^[2]

School of Chemistry The University of Sydney NSW 2006 Australia, Garvan Institute of Medical Research 384 Victoria St Darlinghurst NSW 2010 Australia, School of Medical Sciences UNSW Australia NSW 2052 Australia
School of Chemistry The University of Sydney NSW 2006 Australia
School of Chemistry The University of Sydney NSW 2006 Australia, School of Chemistry and Physics The University of Adelaide SA 5005 Australia
Advanced Photon Source X-ray Science Division Argonne National Laboratory Argonne IL 60439 USA
Garvan Institute of Medical Research 384 Victoria St Darlinghurst NSW 2010 Australia, Charles Perkins Centre The University of Sydney NSW 2006 Australia

Abstract Chromium(III) nutritional supplements are widely consumed for their purported antidiabetic activities. X‐ray fluorescence microscopy (XFM) and X‐ray absorption near‐edge structure (XANES) studies have now shown that non‐toxic doses of [Cr ₃ O(OCOEt) ₆ (OH ₂ ) ₃ ] ⁺ ( A ), a prospective antidiabetic drug that undergoes similar H ₂ O ₂ induced oxidation reactions in the blood as other Cr supplements, was also oxidized to carcinogenic Cr ^VI and Cr ^V in living cells. Single adipocytes treated with A had approximately 1 μm large Cr hotspots containing Cr ^III , Cr ^V , and Cr ^VI (primarily Cr ^VI thiolates) species. These results strongly support the hypothesis that the antidiabetic activity of Cr ^III and the carcinogenicity of Cr ^VI compounds arise from similar mechanisms involving highly reactive Cr ^VI and Cr ^V intermediates, and highlight concerns over the safety of Cr ^III nutritional supplements.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1401851

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Vol. 55 Journal Issue: 5; ISSN 1433-7851

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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Cited by: 52 works

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