Polymer‐based monolithic column with incorporated chiral metal–organic framework for enantioseparation of methyl phenyl sulfoxide using nano‐liquid chromatography

Wang, Xin; Lamprou, Alexandros; Svec, Frantisek; Bai, Yu; Liu, Huwei

doi:10.1002/jssc.201600810

Polymer‐based monolithic column with incorporated chiral metal–organic framework for enantioseparation of methyl phenyl sulfoxide using nano‐liquid chromatography

Journal Article · Thu Nov 17 23:00:00 EST 2016 · Journal of Separation Science

DOI:https://doi.org/10.1002/jssc.201600810· OSTI ID:1401714

Wang, Xin ^[1]; Lamprou, Alexandros ^[2]; Svec, Frantisek ^[2]; Bai, Yu ^[3]; Liu, Huwei ^[3]

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering Peking University Beijing P. R. China, The Molecular Foundry E. O. Lawrence Berkeley National Laboratory Berkeley CA USA
The Molecular Foundry E. O. Lawrence Berkeley National Laboratory Berkeley CA USA
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering Peking University Beijing P. R. China

A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal–organic framework for nano‐liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4‐vinylpyridine‐co‐ethylene dimethacrylate) column, excellent separations of both enantiomers of (±)‐methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metal–organic framework [Zn ₂ (benzene dicarboxylate)(l‐lactic acid)(dmf)], which is synthesized from zinc nitrate, l ‐lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1401714

Journal Information:: Journal of Separation Science, Journal Name: Journal of Separation Science Journal Issue: 23 Vol. 39; ISSN 1615-9306

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

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