Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold

Fu, Qiang; Jia, Weitao; Lau, Grace Y.; Tomsia, Antoni P.

doi:10.1002/jbm.b.33924

Title: Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold

Journal Article · Thu Jun 01 00:00:00 EDT 2017 · Journal of Biomedical Materials Research - Part B: Applied Biomaterials

DOI:https://doi.org/10.1002/jbm.b.33924· OSTI ID:1401325

Fu, Qiang ^[1]; Jia, Weitao ^[2]; Lau, Grace Y. ^[1]; Tomsia, Antoni P. ^[1]

Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley California 94720
Department of Orthopedic Surgery Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai 200233 China

Abstract Development of bioactive glass and ceramic scaffolds intended for the reconstruction of large segmental bone defects remains a challenge for materials science due to the complexities involved in clinical implantation, bone–implant reaction, implant degradation and the multiple loading modes the implants subjected to. A comprehensive evaluation of the mechanical properties of inorganic scaffolds and exploration of new ways to toughen brittle constructs are critical prior to their successful application in loaded sites. A simple and widely adopted approach involves the coating of an inorganic scaffold with a polymeric material. In this work, a systematic evaluation of the influence of a biopolymer, polycaprolactone (PCL), coating on the mechanical performance of bioactive glass scaffolds was carried out. Results from this work indicate that a biopolymer PCL coating was more effective in increasing the compressive strength and reliability of the glass scaffold under compression, but less effective in improving its flexural strength or fracture toughness. This is the first report that reveals the limited successfulness of a polymer coating in improving the toughness of strong scaffolds, suggesting that new and novel ways of toughening inorganic scaffolds should be future research directions for scaffolds applied in loaded sites. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1209–1217, 2018.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: DE‐AC02‐05CH11231

OSTI ID:: 1401325

Journal Information:: Journal of Biomedical Materials Research - Part B: Applied Biomaterials, Journal Name: Journal of Biomedical Materials Research - Part B: Applied Biomaterials Vol. 106 Journal Issue: 3; ISSN 1552-4973

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 14 works

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