Global brain asymmetry is increased in schizophrenia and related to avolition

Núñez, C.; Paipa, N.; Senior, C.; Coromina, M.; Siddi, S.; Ochoa, S.; Brébion, G.; Stephan‐Otto, C.

doi:10.1111/acps.12723

Title: Global brain asymmetry is increased in schizophrenia and related to avolition

Journal Article · Thu Mar 23 00:00:00 EDT 2017 · Acta Psychiatrica Scandinavica

DOI:https://doi.org/10.1111/acps.12723· OSTI ID:1401287

^[1]; Paipa, N. ^[1]; Senior, C. ^[2]; Coromina, M. ^[1]; Siddi, S. ^[3]; Ochoa, S. ^[4]; Brébion, G. ^[4];

^[4]

Parc Sanitari Sant Joan de Déu Sant Boi de Llobregat Barcelona Spain
School of Life &, Health Sciences Aston University Birmingham UK
Parc Sanitari Sant Joan de Déu Sant Boi de Llobregat Barcelona Spain, Facultat de Medicina Universitat de Barcelona Barcelona Spain, Section of Clinical Psychology Department of Education, Psychology, and Philosophy University of Cagliari Cagliari Italy, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid Spain
Parc Sanitari Sant Joan de Déu Sant Boi de Llobregat Barcelona Spain, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid Spain

Objective Schizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole‐brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hemispheres. Method Global gray and white matter asymmetry was calculated from high‐resolution T1 structural images acquired from 24 patients with schizophrenia and 26 healthy controls, age‐ and sex‐matched. Some of the analyses were replicated in a much larger sample ( n = 759) obtained from open‐access online databases. Results Patients with schizophrenia had more global gray matter asymmetry than controls. Additionally, increased gray matter asymmetry was associated with avolition, whereas the inverse relationship was found for anxiety at a trend level. These analyses were replicated in a larger sample and confirmed previous results. Conclusion Our findings suggest that global gray matter asymmetry is related to the concept of developmental stability and is a useful indicator of perturbations during neurodevelopment.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: DE‐FG02‐08ER64581

OSTI ID:: 1401287

Journal Information:: Acta Psychiatrica Scandinavica, Journal Name: Acta Psychiatrica Scandinavica Vol. 135 Journal Issue: 5; ISSN 0001-690X

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: Denmark

Language:: English

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Cited by: 11 works

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