Department of Chemistry Texas A&,M University College Station TX 77843 USA
Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry, the Chinese Academy of Sciences Beijing 100190 P.R. China
Development of a photosensitizing system that can reversibly control the generation of singlet oxygen ( 1 O 2 ) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer–photochromic‐switch dyads were reported as a potential means of the 1 O 2 control in PDT. However, the delivery of such a homogeneous molecular dyad as designed (e.g., optimal molar ratio) is extremely challenging in living systems. Herein we show a Zr‐MOF nanoplatform, demonstrating energy transfer‐based 1 O 2 controlled PDT. Our strategy allows for tuning the ratios between photosensitizer and the switch molecule, enabling maximum control of 1 O 2 generation. Meanwhile, the MOF provides proximal placement of the functional entities for efficient intermolecular energy transfer. As a result, the MOF nanoparticle formulation showed enhanced PDT efficacy with superior 1 O 2 control compared to that of homogeneous molecular analogues.
Park, Jihye, et al. "Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks." Angewandte Chemie (International Edition), vol. 55, no. 25, Apr. 2016. https://doi.org/10.1002/anie.201602417
Park, Jihye, Jiang, Qin, Feng, Dawei, & Zhou, Hong‐Cai (2016). Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks. Angewandte Chemie (International Edition), 55(25). https://doi.org/10.1002/anie.201602417
Park, Jihye, Jiang, Qin, Feng, Dawei, et al., "Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks," Angewandte Chemie (International Edition) 55, no. 25 (2016), https://doi.org/10.1002/anie.201602417
@article{osti_1400971,
author = {Park, Jihye and Jiang, Qin and Feng, Dawei and Zhou, Hong‐Cai},
title = {Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks},
annote = {Abstract Development of a photosensitizing system that can reversibly control the generation of singlet oxygen ( 1 O 2 ) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer–photochromic‐switch dyads were reported as a potential means of the 1 O 2 control in PDT. However, the delivery of such a homogeneous molecular dyad as designed (e.g., optimal molar ratio) is extremely challenging in living systems. Herein we show a Zr‐MOF nanoplatform, demonstrating energy transfer‐based 1 O 2 controlled PDT. Our strategy allows for tuning the ratios between photosensitizer and the switch molecule, enabling maximum control of 1 O 2 generation. Meanwhile, the MOF provides proximal placement of the functional entities for efficient intermolecular energy transfer. As a result, the MOF nanoparticle formulation showed enhanced PDT efficacy with superior 1 O 2 control compared to that of homogeneous molecular analogues. },
doi = {10.1002/anie.201602417},
url = {https://www.osti.gov/biblio/1400971},
journal = {Angewandte Chemie (International Edition)},
issn = {ISSN 1433-7851},
number = {25},
volume = {55},
place = {Germany},
publisher = {Wiley Blackwell (John Wiley & Sons)},
year = {2016},
month = {04}}