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 [1];  [1]
  1. Savannah River Ecology Laboratory, University of Georgia, Drawer E, Aiken SC 29801
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Journal Article: Publisher's Accepted Manuscript
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Additional Journal Information:
Journal Volume: 39; Journal Issue: 1; Related Information: CHORUS Timestamp: 2017-10-20 15:45:51; Journal ID: ISSN 0014-3820
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United States

Citation Formats

Wooten, Michael C., and Smith, Michael H.. LARGE MAMMALS ARE GENETICALLY LESS VARIABLE?. United States: N. p., 2017. Web. doi:10.1111/j.1558-5646.1985.tb04095.x.
Wooten, Michael C., & Smith, Michael H.. LARGE MAMMALS ARE GENETICALLY LESS VARIABLE?. United States. doi:10.1111/j.1558-5646.1985.tb04095.x.
Wooten, Michael C., and Smith, Michael H.. Wed . "LARGE MAMMALS ARE GENETICALLY LESS VARIABLE?". United States. doi:10.1111/j.1558-5646.1985.tb04095.x.
author = {Wooten, Michael C. and Smith, Michael H.},
abstractNote = {},
doi = {10.1111/j.1558-5646.1985.tb04095.x},
journal = {Evolution},
number = 1,
volume = 39,
place = {United States},
year = {Wed May 31 00:00:00 EDT 2017},
month = {Wed May 31 00:00:00 EDT 2017}

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Publisher's Accepted Manuscript

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Cited by: 54works
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  • ABS>To elucidate morphological changes of the central nervous death due to large doses of irradiation (5,000 to 80,000 rad), electron microscopic studies were performed on tissues of the cerebrum and cerebellum exposed to x rays of 6 MeV linear accelerator. The dd-strain male mice, 5 to 6 weeks old, were used. After irradiation of 5,000, 10,000, and 40,000 rad, the intracellular swelling of astrocytic processes and the damage of vasculoastrocytic unit were observed from 0.5 hrs to 72 hrs. Different sorts and degrees of changes, such as pyknosis, chromatolysis, cloudy swelling, tigrolysis, and clear swelling of mitochondria in both nucleusmore » and cytoplasm of various cells (neurons, neurogliocytes, and granule cells) in cerebrum and cerebellum were observed in dependence on exposure dose at different time lapses after irradiation. Moreover, destruction of cell membranes of neurogliocytes and granule cells were observed. Especially, granule cells were more radiovulnerable than other cells. In the irradiation of 5,000 and 10,000 rad, not only destruction of both presynaptic cell membranes and limiting membranes of neuroglia, but also increase in number of the synaptic vesicles were observed at 0.5 hrs after irradiation. However, in the irradiation of 40,000 rad, decrease in number of the synaptic vesicles was observed from beginning and was intensified with lapse of time. After irradiation of much higher dose (80,000 rad), no apparent morphological changes in the central nervous system were observed during extremely short lapse of time until the death. (auth)« less
  • These results point to the capacity of suprelethal total-body irradiation and autologous bone marrow replacement to produce in the host a time-dependent privileged phase of immunologic reactivity during which exposure to alloantigens is more likely to produce unresponsiveness, rather than sensitization. The mechanisms implicated in the mediation of this phenomenon are not clear. Regardless of hypothetical interpretations, however, the current growing interest in total-body irradiation and autologous bone marrow replacement in clinical medicine, and the ease with which this approach appears to produce allogenic unresponsiveness in large mammals, raise the possibility that this method may constitute a highly promising approachmore » to the facilitation of survival of vital transplanted organs in man. This possibility is further supported by the long-term record of the world's longest surviving renal allograft recipient, whose preoperative preparation consisted of total-body irradiation 24 hr before a kidney transplant.« less
  • Maynard Olson has very definite views on the status of DNA sequence technology in relation to the demands of the human genome program. {open_quotes}Efforts to automate conventional technology have almost totally failed...What is currently called {open_quotes}automation{close_quotes} involves the use of alleged labor-saving devices. These have little positive effect - and may even have a negative effect - in embedding to an ever-increasing degree the molecular biologist in the process of sequencing.{close_quotes} That is something that Olson, now working with Leroy Hood at the department of molecular biotechnology at the University of Washington (Seattle, WA), plans to change. The department, establishedmore » in 1991, and partially funded by a $12 million gift from Microsoft`s (Seattle, WA) William Gates III, will take a multidisciplinary, technology-led approach to sequencing development. Olson thinks that the technology that eventually emerges will be {open_quotes}conventional{close_quotes} only in the sense that it will involve Sanger sequencing and electrophoretic separation in some form. 3 refs.« less
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