Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers

Guseva, Elizaveta; Zuckermann, Ronald N.; Dill, Ken A.

doi:10.1073/pnas.1620179114

Title: Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers

Journal Article · Tue Aug 22 00:00:00 EDT 2017 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1620179114· OSTI ID:1399001

Guseva, Elizaveta ^[1]; Zuckermann, Ronald N. ^[2]; Dill, Ken A. ^[1]

Stony Brook Univ., Stony Brook, NY (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

It is not known how life originated. It is thought that prebiotic processes were able to synthesize short random polymers. However, then, how do short-chain molecules spontaneously grow longer? Also, how would random chains grow more informational and become autocatalytic (i.e., increasing their own concentrations)? We study the folding and binding of random sequences of hydrophobic (H) and polar (P) monomers in a computational model. We find that even short hydrophobic polar (HP) chains can collapse into relatively compact structures, exposing hydrophobic surfaces. In this way, they act as primitive versions of today’s protein catalysts, elongating other such HP polymers as ribosomes would now do. Such foldamer catalysts are shown to form an autocatalytic set, through which short chains grow into longer chains that have particular sequences. An attractive feature of this model is that it does not overconverge to a single solution; it gives ensembles that could further evolve under selection. This mechanism describes how specific sequences and conformations could contribute to the chemistry-to-biology (CTB) transition.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1399001

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 36; ISSN 0027-8424

Publisher:: National Academy of Sciences, Washington, DC (United States)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 26 works

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