SPECT in Alzheimer`s disease and the dementias
- Univ. of Texas Southwestern Medical Center, Dallas (United States)
Among 90 patients with a clinical diagnosis of Alzheimer`s disease (AD), two subgroups were identified for special study, including 42 patients who had a history of dementia in one or more first-degree relatives, and 14 who had a diagnosis of early AD. Of the 42 patients with a family history of dementia, 34 out of the 35 patients whose final clinical diagnosis was possible or probable AD had positive SPECT rCBF studies. Studies in the 14 patients thought to have very early AD were positive in 11 cases. This finding suggests that altered cortical physiology, and hence, rCBF, occurs quite early in the course of AD, perhaps before the onset of symptoms. It is possible that Xenon 133 rCBF studies might be used to detect the presence of subclinical AD in a population of individuals at risk to this disorder. Despite the drawbacks of a radionuclide with poor photon energy, Xenon 133, with its low cost and round-the-clock availability, deserves further study. Although the physical characteristics of Xenon 127 might make it preferable as a SPECT tracer, it is still not regularly available, and some instrument systems are not designed to handle its higher photon energies.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- OSTI ID:
- 139692
- Report Number(s):
- CONF-9110368-; ON: TI92014827; TRN: 93:003237-010
- Resource Relation:
- Conference: Brain SPECT perfusion imaging: image acquisition, processing, display, and interpretation, Brookhaven, NY (United States), 8-9 Oct 1991; Other Information: PBD: [1991]; Related Information: Is Part Of Brain SPECT perfusion imaging: Image acquisition, processing, display, and interpretation; Weber, D.A.; Woodhead, A.D.; Vivirito, K.J. [eds.] [Brookhaven National Lab., Upton, NY (United States)]; Devous, M.D. Sr. [ed.] [Texas Univ., Dallas, TX (United States). Southwestern Medical Center]; Tikofsky, R.S. [ed.] [Medical Coll. of Wisconsin, Milwaukee, WI (United States)]; PB: 132 p.
- Country of Publication:
- United States
- Language:
- English
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