Network of nutrient-sensing pathways and a conserved kinase cascade integrate osmolarity and carbon sensing in Neurospora crassa

Huberman, Lori B.; Coradetti, Samuel T.; Glass, N. Louise

doi:10.1073/pnas.1707713114

Network of nutrient-sensing pathways and a conserved kinase cascade integrate osmolarity and carbon sensing in Neurospora crassa

Journal Article · Mon Sep 25 00:00:00 EDT 2017 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1707713114· OSTI ID:1396060

Huberman, Lori B. ^[1]; Coradetti, Samuel T. ^[1]; ^[2]

Plant and Microbial Biology Department, University of California, Berkeley, CA 94720,, Energy Biosciences Institute, University of California, Berkeley, CA 94720,
Plant and Microbial Biology Department, University of California, Berkeley, CA 94720,, Energy Biosciences Institute, University of California, Berkeley, CA 94720,, Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720

Significance

Microbes have evolved complex signaling networks to identify and prioritize utilization of available energy sources. For many fungi, such as Neurospora crassa , this entails distinguishing between an array of carbon sources, including insoluble carbohydrates in plant cell walls. Here, we identified a repressor of the cellulose-response pathway in N . crassa . Using this derepressed mutant, we implicated the conserved hyperosmotic-response MAP kinase pathway in regulating the response of N . crassa to insoluble carbohydrates. We hypothesize that fungal species that degrade plant biomass use osmolarity as a proxy for soluble sugar in the environment to regulate their nutritional responses, enabling tailored production of lignocellulases. This finding could help in battling fungal plant diseases and in the production of second-generation biofuels.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1396060

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 41 Vol. 114; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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