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Title: Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Abstract

A switchable photosensitizer (PS), which can be activated at a spe-cific condition beside light, has tremendous advantages for photo-dynamic therapy (PDT). Herein, we developed a thermo-switchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophor-bide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose (HPC). Self-quenched PS molecules linked in close proximity by pi-pi stacking in T-PPS were easily transited to an active monomeric state by the tempera-ture induced phase transition of polymer backbones. The tempera-ture responsive inter-molecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering (SAXS) and UV-Vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.

Authors:
;  [1]; ;  [1];  [1];  [2];  [1];
  1. Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
  2. X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); National Institutes of Health (NIH) - National Cancer Institute; Northwestern University; National Research Foundation of Korea (NRF); National Institutes of Health (NIH) - National Institute of Biomedical Imaging and Bioengineering (NIBIB)
OSTI Identifier:
1392017
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Volume: 138; Journal Issue: 34; Journal ID: ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

Citation Formats

Park, Wooram, Park, Sin-Jung, Cho, Soojeong, Shin, Heejun, Jung, Young-Seok, Lee, Byeongdu, Na, Kun, and Kim, Dong-Hyun. Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer. United States: N. p., 2016. Web. doi:10.1021/jacs.6b04875.
Park, Wooram, Park, Sin-Jung, Cho, Soojeong, Shin, Heejun, Jung, Young-Seok, Lee, Byeongdu, Na, Kun, & Kim, Dong-Hyun. Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer. United States. doi:10.1021/jacs.6b04875.
Park, Wooram, Park, Sin-Jung, Cho, Soojeong, Shin, Heejun, Jung, Young-Seok, Lee, Byeongdu, Na, Kun, and Kim, Dong-Hyun. Wed . "Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer". United States. doi:10.1021/jacs.6b04875.
@article{osti_1392017,
title = {Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer},
author = {Park, Wooram and Park, Sin-Jung and Cho, Soojeong and Shin, Heejun and Jung, Young-Seok and Lee, Byeongdu and Na, Kun and Kim, Dong-Hyun},
abstractNote = {A switchable photosensitizer (PS), which can be activated at a spe-cific condition beside light, has tremendous advantages for photo-dynamic therapy (PDT). Herein, we developed a thermo-switchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophor-bide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose (HPC). Self-quenched PS molecules linked in close proximity by pi-pi stacking in T-PPS were easily transited to an active monomeric state by the tempera-ture induced phase transition of polymer backbones. The tempera-ture responsive inter-molecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering (SAXS) and UV-Vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.},
doi = {10.1021/jacs.6b04875},
journal = {Journal of the American Chemical Society},
issn = {0002-7863},
number = 34,
volume = 138,
place = {United States},
year = {2016},
month = {8}
}