Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Journal Article · Wed Aug 17 00:00:00 EDT 2016 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.6b04875· OSTI ID:1392017

Park, Wooram; Park, Sin-Jung ^[1]; Cho, Soojeong; Shin, Heejun ^[1]; Jung, Young-Seok ^[1]; Lee, Byeongdu ^[2]; Na, Kun ^[1]; Kim, Dong-Hyun

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1. Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
2. X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States

A switchable photosensitizer (PS), which can be activated at a spe-cific condition beside light, has tremendous advantages for photo-dynamic therapy (PDT). Herein, we developed a thermo-switchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophor-bide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose (HPC). Self-quenched PS molecules linked in close proximity by pi-pi stacking in T-PPS were easily transited to an active monomeric state by the tempera-ture induced phase transition of polymer backbones. The tempera-ture responsive inter-molecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering (SAXS) and UV-Vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.

• Research Organization: Argonne National Laboratory (ANL)
• Sponsoring Organization: USDOE Office of Science - Office of Basic Energy Sciences; National Institutes of Health (NIH) - National Cancer Institute; Northwestern University; National Research Foundation (NRF) of Korea; National Institutes of Health (NIH) - National Institute of Biomedical Imaging and Bioengineering (NIBIB)
• DOE Contract Number: AC02-06CH11357
• OSTI ID: 1392017
• Journal Information: Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 34 Vol. 138; ISSN 0002-7863
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: English