Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)
Patent
·
OSTI ID:1390247
Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-06CH11357
- Assignee:
- The Board of Regents of the University of Texas System
- Patent Number(s):
- 9,757,379
- Application Number:
- 14/442,485
- OSTI ID:
- 1390247
- Resource Relation:
- Patent File Date: 2013 Nov 14
- Country of Publication:
- United States
- Language:
- English
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