Amphiphilic Nanoparticles Control the Growth and Stability of Lipid Bilayers with Open Edges

Shin, Sun Hae Ra; Lee, Hee-Young; Bishop, Kyle J.  M.

doi:10.1002/anie.201504362

Title: Amphiphilic Nanoparticles Control the Growth and Stability of Lipid Bilayers with Open Edges

Journal Article · Thu Jul 23 00:00:00 EDT 2015 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.201504362· OSTI ID:1386356

Shin, Sun Hae Ra; Lee, Hee-Young; Bishop, Kyle J. M.

Molecular amphiphiles self-assemble in polar media to form ordered structures such as micelles and vesicles essential to a broad range of industrial and biological processes. Some of these architectures such as bilayer sheets, helical ribbons, and hollow tubules are potentially useful but inherently unstable owing to the presence of open edges that expose the hydrophobic bilayer core. Here, we describe a strategy to stabilize open bilayer structures using amphiphilic nanoparticle surfactants that present mixtures of hydrophilic and hydrophobic ligands on their surface. We observe that these particles bind selectively to the open edge of bilayer membranes to stabilize otherwise transient amphiphile assemblies. We show how such particles can precisely control the size of lipid tubules, how they can inhibit the formation of undesirable assemblies such as gallstone precursors, and how they can stabilize free-floating lipid microdiscs.

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Research Organization:: Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

DOE Contract Number:: SC0000989

OSTI ID:: 1386356

Journal Information:: Angewandte Chemie (International Edition), Vol. 54, Issue 37; Related Information: CBES partners with Northwestern University (lead); Harvard University; New York University; Pennsylvania State University; University of Michigan; University of Pittsburgh; ISSN 1433-7851

Publisher:: Wiley

Country of Publication:: United States

Language:: English

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Title: Amphiphilic Nanoparticles Control the Growth and Stability of Lipid Bilayers with Open Edges

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