Polymeric peptide pigments with sequence-encoded properties

Lampel, Ayala; McPhee, Scott A.; Park, Hang-Ah; Scott, Gary G.; Humagain, Sunita; Hekstra, Doeke R.; Yoo, Barney; Frederix, Pim W.  J.  M.; Li, Tai-De; Abzalimov, Rinat R.; Greenbaum, Steven G.; Tuttle, Tell; Hu, Chunhua; Bettinger, Christopher J.; Ulijn, Rein V.

doi:10.1126/science.aal5005

Polymeric peptide pigments with sequence-encoded properties

Journal Article · Thu Jun 08 00:00:00 EDT 2017 · Science

DOI:https://doi.org/10.1126/science.aal5005· OSTI ID:1379428

; ; ; ; ; ; ; ; ; ; Greenbaum, Steven G.; ; ; Bettinger, Christopher J.;

Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence. Oxidative polymerization can be tuned in a sequence-dependent manner, resulting in peptide sequence–encoded properties such as UV absorbance, morphology, coloration, and electrochemical properties over a considerable range. Short peptides have low barriers to application and can be easily scaled, suggesting near-term applications in cosmetics and biomedicine.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NSFU.S. AIR FORCE- OFFICE OF SCIENTIFIC RESEARCHFOREIGN

OSTI ID:: 1379428

Journal Information:: Science, Journal Name: Science Journal Issue: 6342 Vol. 356; ISSN 0036-8075

Publisher:: AAAS

Country of Publication:: United States

Language:: ENGLISH

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