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Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy

Journal Article · · Radiation Research
DOI:https://doi.org/10.1667/RR14412.1· OSTI ID:1379362
 [1];  [2];  [3];  [4]
  1. Massachusetts General Hospital/Harvard Medical School, Boston, MA (United States)
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  3. Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)
  4. Brookhaven National Lab. (BNL), Upton, NY (United States)
+ Show Author Affiliations
Although clinical studies with carbon ions have been conducted successfully in Japan and Europe, the limited radiobiological information about charged particles that are heavier than protons remains a significant impediment to exploiting the full potential of particle therapy. There is growing interest in the U.S. to build a cancer treatment facility that utilizes charged particles heavier than protons. Therefore, it is essential that additional radiobiological knowledge be obtained using state-of-the-art technologies and biological models and end points relevant to clinical outcome. Currently, most such ion radiotherapy-related research is being conducted outside the U.S. This article addresses the substantial contributions to that research that are possible at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), which is the only facility in the U.S. at this time where heavy-ion radiobiology research with the ion species and energies of interest for therapy can be done. Here in this paper, we briefly discuss the relevant facilities at NSRL and how selected charged particle biology research gaps could be addressed using those facilities.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE; National Institutes of Health (NIH)
DOE Contract Number:
AC02-05CH11231
OSTI ID:
1379362
Journal Information:
Radiation Research, Journal Name: Radiation Research Journal Issue: 6 Vol. 185; ISSN 0033-7587
Publisher:
Radiation Research Society
Country of Publication:
United States
Language:
English

References (10)

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Charged particle therapy—optimization, challenges and future directions journal May 2013
Biology of Charged Particles journal January 2009
Inactivation of Human Kidney Cells by High-Energy Monoenergetic Heavy-Ion Beams journal October 1979
Charged particles in radiation oncology journal December 2009
Radiation-Induced DNA Damage in Tumors and Normal Tissues. III. Oxygen Dependence of the Formation of Strand Breaks and DNA-Protein Crosslinks journal May 1995
Image-guided small animal radiation research platform: calibration of treatment beam alignment journal January 2009
Optimizing Dose and Fractionation for Stereotactic Body Radiation Therapy
  • Timmerman, Robert; Bastasch, Michael; Saha, Debabrata
  • IMRT, IGRT, SBRT - Advances in the Treatment Planning and Delivery of Radiotherapy https://doi.org/10.1159/000106046
book January 2007
Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience journal February 2015
TOPAS: An innovative proton Monte Carlo platform for research and clinical applications: TOPAS: An innovative proton Monte Carlo platform journal October 2012

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