Targeted Molecular Imaging of Cancer Cells Using MS2-Based 129 Xe NMR
Journal Article
·
· Bioconjugate Chemistry
- Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
- Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
- Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Physical Biosciences Division
Targeted, selective, and highly sensitive 129Xe NMR nanoscale biosensors have been synthesized using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized 129Xe NMR signal contrast and hyper-CEST 129Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized 129Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Fusion Energy Sciences (FES); National Institutes of Health (NIH)
- Grant/Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1378338
- Journal Information:
- Bioconjugate Chemistry, Vol. 27, Issue 8; ISSN 1043-1802
- Publisher:
- American Chemical SocietyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Cited by: 19 works
Citation information provided by
Web of Science
Web of Science
Nanoparticle-Based Contrast Agents for 129 Xe HyperCEST NMR and MRI Applications
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journal | November 2019 |
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