Influenza-Omics and the Host Response: Recent Advances and Future Prospects

Powell, Joshua D.; Waters, Katrina M.

doi:10.3390/pathogens6020025

Title: Influenza-Omics and the Host Response: Recent Advances and Future Prospects

Journal Article · Sat Jun 10 00:00:00 EDT 2017 · Pathogens

DOI:https://doi.org/10.3390/pathogens6020025· OSTI ID:1378027

Powell, Joshua D. ^[1];

^[2]

Battelle Memoria Institute, Aberdeen, MD (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Influenza A viruses (IAV) continually evolve and have the capacity to cause global pandemics. Because IAV represents an ongoing threat, identifying novel therapies and host innate immune factors that contribute to IAV pathogenesis is of considerable interest. This review summarizes the relevant literature as it relates to global host responses to influenza infection at both the proteome and transcriptome level. Here, the various –omics infection systems that include but are not limited to ferrets, mice, pigs and even controlled infection of humans are reviewed. Discussion focuses on recent advances, remaining challenges, and knowledge gaps as it relates to influenza-omics infection outcomes.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1378027

Report Number(s):: PNNL-SA-126286; PATHCD; 453060036

Journal Information:: Pathogens, Vol. 6, Issue 2; ISSN 2076-0817

Country of Publication:: United States

Language:: English

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Cited by: 11 works

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influenza
host responses
proteome
transcriptome

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