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Title: Distinguishing d - and l -aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry

Abstract

Ion mobility spectrometry (IMS) was utilized to separate Aβ peptide variants containing isomeric asparic and isoaspartic acid residues with either al- ord-form. The abundance of each variant is of great interest in Alzheimer's disease studies and also to evaluate how often these modifications are occurring in other environmental and biological samples.

Authors:
ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Biological Sciences Division; Pacific Northwest National Laboratory; Richland; USA
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1373849
Report Number(s):
PNNL-SA-124064
Journal ID: ISSN 1359-7345; CHCOFS; 49531; 48680; 453040220
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
ChemComm
Additional Journal Information:
Journal Volume: 53; Journal Issue: 56; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Environmental Molecular Sciences Laboratory

Citation Formats

Zheng, Xueyun, Deng, Liulin, Baker, Erin S., Ibrahim, Yehia M., Petyuk, Vladislav A., and Smith, Richard D. Distinguishing d - and l -aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry. United States: N. p., 2017. Web. doi:10.1039/C7CC03321D.
Zheng, Xueyun, Deng, Liulin, Baker, Erin S., Ibrahim, Yehia M., Petyuk, Vladislav A., & Smith, Richard D. Distinguishing d - and l -aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry. United States. doi:10.1039/C7CC03321D.
Zheng, Xueyun, Deng, Liulin, Baker, Erin S., Ibrahim, Yehia M., Petyuk, Vladislav A., and Smith, Richard D. Sun . "Distinguishing d - and l -aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry". United States. doi:10.1039/C7CC03321D.
@article{osti_1373849,
title = {Distinguishing d - and l -aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry},
author = {Zheng, Xueyun and Deng, Liulin and Baker, Erin S. and Ibrahim, Yehia M. and Petyuk, Vladislav A. and Smith, Richard D.},
abstractNote = {Ion mobility spectrometry (IMS) was utilized to separate Aβ peptide variants containing isomeric asparic and isoaspartic acid residues with either al- ord-form. The abundance of each variant is of great interest in Alzheimer's disease studies and also to evaluate how often these modifications are occurring in other environmental and biological samples.},
doi = {10.1039/C7CC03321D},
journal = {ChemComm},
issn = {1359-7345},
number = 56,
volume = 53,
place = {United States},
year = {2017},
month = {1}
}